Fig. 5
From: IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer
IRF-2 inhibiting the Wnt/β-catenin signaling pathway depends on the regulation of AMER-1. A, D Western blotting verified that the negative regulatory effect of IRF-2 on Wnt/β-catenin pathway was dependent on AMER-1. B, E Colony formation ability was increased when AMER-1 was knocked down, even when IRF-2 was overexpressed. The opposite result was found when AMER-1 was over-expressed even if the IRF-2 was knocked down. C, F EdU assays also showed that the cell proliferation ability depended on AMER-1 regulation