Fig. 4

mPRα promoted LUAD cell growth in the xenograft model. A–C xenograft mouse tumor model was established in BALB/C nude mice accordingly. MPRα knockdown or overexpression lentivirus infected A549 cells were injected under the skin of the left flank of nude mice. The tumor volume B was measured every 3 days for 21 days; on day 21, mice were sacrificed, and the tumor weight was measured (C); D the protein levels of mPRα, ki67, and PCNA in tumor tissues were examined using IHC staining. E The protein levels of mPRα, PCNA, p-STAT3, STAT3, VEGF, and HIF1α in tumor tissues were examined using Immunoblotting. **P < 0.01, compared to si-NC. ## P < 0.01, ### P < 0.005, compared to NC