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Table 2 Association of TXNIP cg19693031 methylation and GLUT1 rs841853 with fasting blood glucose

From: Interaction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non-diabetics

  β p-value
TXNIP cg19693031 (ref: ≥ Q3)
 Q2–Q3 − 0.0236 0.965
 Q1–Q2 1.0317 0.058
 < Q1 1.3336 0.019
P for trend   0.005
GLUT1 rs841853 (ref: CC)
 CA + AA − 0.4576 0.232
Sex (ref: Women)
 Men 2.4784  < .001
Age 0.1935  < .001
BMI 0.1647 0.006
Cigarette smoking (ref: No)
 Yes 0.7118 0.166
Alcohol drinking (ref: No)
 Yes 1.2013 0.086
Triglyceride 0.0031 0.146
HDL-C − 0.0338 0.037
LDL-C 0.0094 0.112
Hypertension (ref: No)
 Yes 0.3245 0.540
Exercise (ref: No)
 Yes − 0.3790 0.362
Tea intake (ref: No)
 Yes 0.1308 0.742
Coffee intake (ref: No)
 Yes − 0.2297 0.564
Vegetarian diet (ref: No)
 Yes − 1.9887 0.004
TXNIP cg19693031*SLC2A1 rs841853 p-value = 0.036
  1. TXNIP thioredoxin-interacting protein, GLUT1 glucose transporter 1, β beta coefficient, ref reference, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, *: interaction term