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Table 2 Association of TXNIP cg19693031 methylation and GLUT1 rs841853 with fasting blood glucose

From: Interaction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non-diabetics

 

β

p-value

TXNIP cg19693031 (ref: ≥ Q3)

 Q2–Q3

− 0.0236

0.965

 Q1–Q2

1.0317

0.058

 < Q1

1.3336

0.019

P for trend

 

0.005

GLUT1 rs841853 (ref: CC)

 CA + AA

− 0.4576

0.232

Sex (ref: Women)

 Men

2.4784

 < .001

Age

0.1935

 < .001

BMI

0.1647

0.006

Cigarette smoking (ref: No)

 Yes

0.7118

0.166

Alcohol drinking (ref: No)

 Yes

1.2013

0.086

Triglyceride

0.0031

0.146

HDL-C

− 0.0338

0.037

LDL-C

0.0094

0.112

Hypertension (ref: No)

 Yes

0.3245

0.540

Exercise (ref: No)

 Yes

− 0.3790

0.362

Tea intake (ref: No)

 Yes

0.1308

0.742

Coffee intake (ref: No)

 Yes

− 0.2297

0.564

Vegetarian diet (ref: No)

 Yes

− 1.9887

0.004

TXNIP cg19693031*SLC2A1 rs841853

p-value = 0.036

  1. TXNIP thioredoxin-interacting protein, GLUT1 glucose transporter 1, β beta coefficient, ref reference, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, *: interaction term
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Journal of Translational Medicine

ISSN: 1479-5876

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