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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

Fig. 2

Identification of LLPS subtypes of LGG by using NMF algorithm. A Volcano plot showed DEGs (P < 0.05 and |log2FC|> 1.5) between LGG tissues in TCGA cohort and normal brain tissues in GTEx database. The gene names with top three log2FC and lower three log2FC were highlighted in the groups of clients, regulators and scaffolds respectively. B Venn diagram identified 225 prognostic LLPS-related DEGs. C Consensus map of NMF clustering. D tSNE plot for the expression profiles of 225 prognostic LLPS-related DEGs to distinguish LLPS subtypes. E Heatmap showed the expression levels of 225 prognostic LLPS-related DEGs among LLPS subtypes. F Kaplan–Meier survival analysis exhibited significantly different OS among LLPS subtypes

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Journal of Translational Medicine

ISSN: 1479-5876

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