Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment

Table 1 Driver mutations of melanoma cell lines used

Cell line	Driver mutation
B16F10	Multiple mutations, 563 in expressed genes, including Pten, Trp53. None in Braf, c-Kit, Kras or Nras [60]
RET1	Overexpression of human RET proto-oncogene driven by the mouse metallothionein1 (MT) promotor [27, 43]
WT31	Tyr∷Nras^Q61K/°; INK4a^−/− [28]
HCmel12	HGF-CDK4(R24C) [29]
D4M	Tyr::CreER;Braf^CA;Pten^lox/lox (30)

ISSN: 1479-5876