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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Heart-specific DNA methylation analysis in plasma for the investigation of myocardial damage

Fig. 1

Identification of heart-specific hypermethylation markers with MCTA-seq. a Heatmap of 6 identified heart-specific hypermethylation marker methylation levels and the expression levels in 9 different tissues, including the heart and WBCs. Each column represents one tissue type, and each row represents a marker. The markers (n = 6) are ranked by their methylation levels in the tissue, as calculated by their MePM values of MCTA-seq. In the heatmap, blue indicates low, white and yellow indicate intermediate and red indicates high DNA methylation values, which are shown as log2(MePM) (left). The expression levels are shown by the log2(z-score) (right). See the online methods for the identification of heart-specific hypermethylation markers. bg Comparison of the representative heart-specific marker methylation levels in the plasma of MI patients (n = 20), normal plasma (n = 202), and WBCs (n = 81). MI indicates patients with acute myocardial, PN indicates normal control individuals, and WBC indicates samples of white blood cell. ****P < 0.0001. Two-tailed MWW test

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