Fig. 3

Transcriptome and proteome-based clustering of pan-cancer cell lines. a Expression of Epithelial and mesenchymal proteins across a panel of cancel cell lines. Layer from outside to inside: layer 1: tissue of origin, layer 2: expression of epithelial proteins (Clockwise-KRT18, KRT8, ANXA4, SDC1, EPCAM, CDH1, DSG3, MUC1, S100A14, SCNN1A), layer 3: expression of mesenchymal proteins (Clockwise-ITGA5, LAMC1, VIM, ITGB4, TUBA, LAMC2, FN, COL6A1, ITGB6, ZEB1), layer 4: EMT phenotype. b Principal component analysis of cell lines based on transcriptomics data from CCLE or PRM-based proteomics data coloured based on EMT score from Tan et al.