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Table 3 Univariate and multivariate Cox’s proportional risk model for overall survival of HCC patients (n = 85)

From: Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo

Variables

Univariate analysis

Multivariable analysis

β

HR

95%CI

P value

β

HR

95%CI

P value

Age (≥ 50 vs. < 50)

0.03

1.03

0.99–1.06

0.135

    

Sex (male vs. female)

− 0.11

0.89

0.31–2.63

0.837

    

Liver cirrhosis (positive vs. negative)

0.13

1.14

0.49–2.67

0.757

    

AFP (> 400 ng/ml vs. ≤ 400 ng/ml )

0.93

2.54

0.87–7.45

0.090

    

Tumour size (≥ 5 cm vs. < 5 cm)

0.81

2.25

0.89–5.69

0.087

    

Tumour number (multiple vs. single)

0.12

1.13

0.39–3.31

0.822

    

Distant metastasis (positive vs. negative)

1.23

3.42

0.44–26.73

0.242

    

Lymphatic metastasis (positive vs. negative)

0.61

1.85

0.55–6.21

0.323

    

DNA content of HBV (positive vs. negative)

0.12

1.13

0.50–2.53

0.768

    

Satellite nodules (positive vs. negative)

1.35

3.86

1.59–9.40

0.003

0.92

2.51

0.78–8.08

0.124

BCLC grade (A vs. B vs. C)

0.42

1.53

0.98–2.38

0.061

0.01

1.01

0.57–1.79

0.983

MVI (positive vs. negative)

0.89

2.43

1.46–4.04

0.001

2.04

7.73

2.24–26.72

0.001

Edmondson-Steiner grade (> II vs. I–II)

1.91

6.73

1.58–28.63

0.010

2.36

10.57

2.14–52.15

0.004

LINC01146 expression (high vs. low)

− 1.32

0.27

0.09–0.78

0.015

− 0.97

0.38

0.16–0.92

0.033

  1. vs. versus, AFP alpha fetoprotein, BCLC: Barcelona clinic liver cancer grade, MVI microvascular invasion
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Journal of Translational Medicine

ISSN: 1479-5876

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