Fig. 8From: Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter regionSchematic model of Neat1 regulation of cardiac fibrosis. Neat1 recruits EZH2 to bind to the promoter region of Smad7, thereby inhibiting the expression of Smad7. This leads to the activation of p-Smad2/3, causing the activation of fibroblasts and ECM and ultimately leading to cardiac fibrosisBack to article page