Table 2 Categories of pathways predicted to involve the candidate drugs
From: From GWAS to drug screening: repurposing antipsychotics for glioblastoma
Category | Pathway name | E-score* | P value |
|---|---|---|---|
Mitotic cell cycle | Mitotic nuclear envelope disassembly | − 0.73 | 5.63E−06 |
Mitotic cell cycle | − 0.70 | 1.61E−05 | |
G1/S transition of mitotic cell cycle | − 0.59 | 5.60 E−04 | |
Mitotic metaphase plate congression | − 0.52 | 3.03 E−03 | |
Mitotic sister chromatid segregation | − 0.51 | 4.24 E−03 | |
Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | − 0.51 | 4.33 E−03 | |
Negative regulation of mitotic cell cycle | 0.50 | 4.76 E−03 | |
Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | − 0.47 | 1.04 E−02 | |
Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | − 0.45 | 1.57 E−02 | |
Mitotic cell cycle arrest | 0.44 | 1.97 E−02 | |
ER stress | Endoplasmic reticulum unfolded protein response | 0.70 | 1.49 E−05 |
Response to endoplasmic reticulum stress | 0.66 | 6.22 E−05 | |
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 0.56 | 1.07 E−03 | |
Glucose transport | Regulation of glucose transport | − 0.70 | 1.79 E−05 |
Glucose transport | − 0.51 | 4.59 E−03 | |
Negative regulation of glucose import | 0.49 | 7.22 E−03 | |
Cellular response to glucose starvation | 0.46 | 1.37 E−02 | |
Autophagy | Positive regulation of autophagy | 0.54 | 2.01 E−03 |
Autophagy | 0.52 | 3.08 E−03 | |
Regulation of autophagy | 0.47 | 1.15 E−02 |