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Table 2 Association of 20 vitamin D genetic variants in MS GWAS dataset

From: Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis

SNP

Serum 25OHD GWAS

MS GWAS

EA

NEA

EAF

Beta

SE

p val

rs8063565

C

G

0.733

− 0.002

0.019

0.928

rs11542462

A

G

0.130

0.026

0.025

0.292

rs964184

C

G

0.134

− 0.014

0.024

0.570

rs1260326

C

T

0.601

0.005

0.017

0.749

rs1800588

T

C

0.219

− 0.005

0.020

0.786

rs10908469

C

A

0.278

− 0.021

0.018

0.262

rs1532085

G

A

0.607

− 0.006

0.017

0.717

rs2131925

G

T

0.318

0.005

0.020

0.805

rs7528419

A

G

0.784

0.025

0.020

0.225

rs804281

G

A

0.576

0.028

0.017

0.098

rs532436

A

G

0.210

0.042

0.020

0.034

rs10822145

T

C

0.472

− 0.014

0.016

0.398

rs1660818

A

G

0.317

0.000

0.018

0.999

rs2276360

C

G

0.785

− 0.105

0.018

0.000

rs12317268

G

A

0.162

0.037

0.022

0.084

rs11182428

C

T

0.514

0.017

0.017

0.302

rs61003750

C

G

0.300

0.029

0.018

0.122

rs142158911

A

G

0.120

− 0.071

0.026

0.006

rs62115743

T

C

0.077

− 0.056

0.031

0.071

rs1841850

C

A

0.114

− 0.051

0.025

0.040

  1. SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency; Beta is the regression coefficient based on the vitamin D raising effect allele, SE standard error
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Journal of Translational Medicine

ISSN: 1479-5876

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