Fig. 6

Cluster127 in imprinted Dlk1-Dio3 locus is potential biomarker for cancers. (A) Expression relationships of the Cluster127 in 11 cancer types were displayed. (B) Kaplan–Meier plot for TCGA patients with different risk scores in cancers which Cluster127 is significantly associated with survival in BRCA, CESC, COAD, HNSC, KICH, KIRC, LGG, LUSC. (C) KEGG pathway analysis was applied for mRNAs co-expressed with Cluster127 in BLCA and LIHC separately. (D) A model illustrating the lincRNA of Cluster127 and mRNA co-expressed in LIHC cooperatively mediate the pathway dysregulation which may be implicated in cancer-related processes. LincRNAs in Cluster127 cooperatively mediated PI3K-AKT signaling pathway. The representative component of the pathway was shown. Protein coding genes co-expressed with lincRNA are indicated in red. The lines between them show the co-expression of lincRNA to genes. Cancers related to PI3K-AKT signaling pathway were linked with the literature reported