Fig. 2From: Optimization of metabolism to improve efficacy during CAR-T cell manufacturingIn vitro expansion of T cells and CAR-T cells require proper metabolism(directly or indirectly inhibit glycolysis) to maintain undifferentiated state, which can extend the duration in vivo and enhance anti-tumor activity; However, in vivo it is necessary to enhance metabolic (glycolysis or OXPHOS) activity to maintain high invasion potential and killing functionBack to article page