Fig. 6

Construction of the prognostic model of CRC patients based on ligand-receptor pairs. A Volcano plot showing ligand-receptor pairs that significantly influence survival in the GSE39582 dataset. B The bubble plot shows the mean hazard ratios (HRs) of all genes in each GO-BP term enriched in survival-related ligand-receptor pairs. C Risk curve (upper panel) and dot plot (bottom panel) describe the relationship between the risk score and patient survival status. D KM survival analysis illustrated the survival condition of high-risk and low-risk patients in the training group, internal validation group and external validation group. E ROC curve analysis was performed to estimate the prognostic capacity of the ligand-receptor pair predictive model. F Calibration plots of the prognostic model for predicting survival rates in all cohorts. G The nomogram of the CRC prognostic model was constructed based on the ligand-receptor risk score and clinicopathological data in GSE39582