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Table 2 Characteristics of 232 NSCLC patients and with chi-square test for categorical variables

From: Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

Characteristics

WBRT

(n = 84)

Local Radiotherapy (n = 65)

WBRT + Boost (n = 83)

P value

Age, years

53(28–77)

56(38–81)

53(33–78)

 

 > 60

21(25.0)

24(36.9)

23(27.7)

0.263

 ≤ 60

63(75.0)

41(63.1)

60(72.3)

 

Sex

 Female

51(60.7)

43(66.2)

55(66.3)

0.703

 Male

33(39.3)

22(33.8)

28(33.7)

 

Smoking status

 Never

61(72.6)

48(73.8)

73(88.0)

0.031

 Former/current

23(27.4)

17(26.2)

10(12.0)

 

EGFR mutation

 Exon 18

1(1.2)

0

2(2.4)

0.462

 Exon 19

36(42.9)

24(36.9)

36(43.4)

 

 Exon 21

41(48.8)

38(58.5)

36(43.4)

 

 Unclear

6(7.1)

3(4.6)

9(10.8)

 

Systemic therapy

 First-line EGFR TKIs

38(45.2)

30(46.2)

40(48.2)

0.927

 Second-line EGFR TKIs

46(54.8)

35(53.8)

43(51.8)

 

Lung-molGPA

 1–2

56(66.6)

19(29.2)

28(33.7)

 < 0.001

 2.5–3

24(28.6)

33(50.8)

41(49.4)

 

 3.5–4

2(2.4)

12(18.5)

13(15.7)

 

 Unclear

2(2.4)

1(1.5)

1(1.2)

 

Brain metastatic time

 Initial treatment

47(56.0)

41(63.1)

56(67.5)

0.303

 In the course of treatment

37(44.0)

24(36.9)

27(32.5)

 
  1. EGFR epidermal growth factor receptor, TKI tyrosine kinase inhibitors