Fig. 2

OVCARE’s data commons infrastructure and software stack. The overall data commons infrastructure comprises of five main components: (1) A clinical database (REDCap) that consolidates and manages clinical data collections from the BC Cancer Registry and the Cheryl Brown Gynecological Cancers Outcomes Unit, (2) a Library Information Management System (OpenSpecimen) that stores and manages biospecimens collected from consented participants at different hospital sites (i.e. Vancouver General Hospital, the University of British Columbia Hospital, BC Cancer Vancouver, and now a few more centers in BC, (3) the cBioPortal that supports the exploration, analysis and visualization of clinical attributes and molecular profiles from patient tumor samples, (4) the OVCARE Resource Portal (ORP) that governs data and resource sharing based on stipulated protocols, standard operating procedures and research ethics, and (5) the Research Community (this includes the OVCARE internal research and informatics team, and the broader research community that OVCARE serves). Each of the components (REDCap, OpenSpecimen, cBioPortal, ORP) identified to meet our research needs are separately hosted in our hospital’s computing environment and programmatically interlinked through API calls. The data from the different domains are interlinked using system-wide unique identifiers that link patients to their biospecimen collections and molecular/genomics data. To access the amassed clinical and biospecimen collections, authenticated researchers in the OVCARE research community send data and sample acquisition requests to the ORP through which those requests are met by informatics staff, if all stipulated requirements including ethics approval are met. Upon successful data and sample acquisition, researchers conduct their respective studies, and the data generated (raw or processed, and/ biospecimen derivatives) from their research are retuned to OVCARE making it available for re-purposing/secondary use. Furthermore, molecular data returned to the data commons are linked back to the available and stored patient biospecimens. Together with clinical outcomes, these molecular profiles are further explored, analyzed and visualized using the cBioPortal