Table 2 List of differentially expressed genes of TLR signalling pathways between patients and healthy controls

Toll like receptor

TLR10

–

–

–

TLR3

0.4231

0.0478

–

0.2398

0.0016

TLR9

4.0564

0.0009

2.5115

0.03556

2.6805

0.023

SIGIRR

2.2314

0.0105

2.1148

0.0447

–

Effectors

FADD

2.022

0.0302

–

2.2185

0.0133

IRAK1

5.4967

0.0003

3.3386

0.0193

3.4884

0.0089

IRAK2

–

–

–

Interacting proteins and adaptors

CD14

2.1815

0.0116

–

2.3584

0.0033

HSPA1A

4.0346

0.0017

2.3591

0.0183

3.7515

0.0039

MAPK8IP3

2.0727

0.0129

–

–

TOLLIP

2.4367

0.0113

2.111

0.0039

–

TIRAP

2.4229

0.0012

–

–

Regulation of adaptive immunity

IFNG

–

–

0.173

0.0006

IL10

–

–

2.6697

0.0249

IL12A

–

–

–

IL1B

–

0.4534

0.0017

0.4067

0.0025

IL2

–

–

–

Downstream pathway of toll like receptors

 NFKB signalling

FADD

2.022

0.0302

–

2.2185

0.0133

IL10

–

–

2.6697

0.0249

IL1B

–

0.4534

0.0017

0.4067

0.0025

IRAK1

5.4967

0.0003

3.3386

0.0193

3.4884

0.0089

IRAK2

–

–

–

MAP4K4

2.0512

0.0018

–

–

NFKB2

2.2645

0.0060

–

–

NFKBIA

2.0441

0.0170

–

–

NFRKB

2.056

0.0292

–

–

TNFRSF1A

2.5753

0.0015

–

–

CXCL8

–

–

0.0959

0.0422

LTA

–

–

0.489

0.0157

 JNK/p38 signalling

ELK1

2.9532

0.0012

2.2857

0.0128

2.4822

0.0054

IL1B

–

0.4534

0.0017

0.4067

0.0025

MAPK8IP3

2.0727

0.0129

–

–

 JAK/STATsignalling

CCL2

–

–

–

IFNG

–

–

0.173

0.0006

IL2

–

–

–

 Interferon regulatory factor signalling

CXCL10

–

–

–

IFNB1

–

–

–

IFNG

–

–

0.173

0.0006

IRF1

2.7619

0.0012

–

–

TBK1

–

–

0.4399

0.0013

 Cytokine signalling

CCL2

–

–

–

IL1B

–

0.4534

0.0016

0.4067

0.0025

IRAK1

5.4967

0.0003

3.3386

0.0193

3.4884

0.0089

IRAK2

–

–

–

SIGIRR

2.2314

0.0105

2.1148

0.0045

–

TNFRSF1A

2.5753

0.0015

–

–

 NF/IL6 pathway

PTGS2

0.4895

0.0038

–

0.1811

0.0002