Table 2 List of differentially expressed genes of TLR signalling pathways between patients and healthy controls
| Gene symbol | Gene | Neutrophils | ||
|---|---|---|---|---|
| C-LC | D-LC | ACLF | ||
|
Fold change P value |
Fold change P value |
Fold change P value | ||
| Toll like receptor | TLR10 | – | – | – |
| TLR3 |
0.4231 0.0478 | – |
0.2398 0.0016 | |
| TLR9 |
4.0564 0.0009 |
2.5115 0.03556 |
2.6805 0.023 | |
| SIGIRR |
2.2314 0.0105 |
2.1148 0.0447 | – | |
| Effectors | FADD |
2.022 0.0302 | – |
2.2185 0.0133 |
| IRAK1 |
5.4967 0.0003 |
3.3386 0.0193 |
3.4884 0.0089 | |
| IRAK2 | – | – | – | |
| Interacting proteins and adaptors | CD14 |
2.1815 0.0116 | – |
2.3584 0.0033 |
| HSPA1A |
4.0346 0.0017 |
2.3591 0.0183 |
3.7515 0.0039 | |
| MAPK8IP3 |
2.0727 0.0129 | – | – | |
| TOLLIP |
2.4367 0.0113 |
2.111 0.0039 | – | |
| TIRAP |
2.4229 0.0012 | – | – | |
| Regulation of adaptive immunity | IFNG | – | – |
0.173 0.0006 |
| IL10 | – | – |
2.6697 0.0249 | |
| IL12A | – | – | – | |
| IL1B | – |
0.4534 0.0017 |
0.4067 0.0025 | |
| IL2 | – | – | – | |
| Downstream pathway of toll like receptors | ||||
| NFKB signalling | FADD |
2.022 0.0302 | – |
2.2185 0.0133 |
| IL10 | – | – |
2.6697 0.0249 | |
| IL1B | – |
0.4534 0.0017 |
0.4067 0.0025 | |
| IRAK1 |
5.4967 0.0003 |
3.3386 0.0193 |
3.4884 0.0089 | |
| IRAK2 | – | – | – | |
| MAP4K4 |
2.0512 0.0018 | – | – | |
| NFKB2 |
2.2645 0.0060 | – | – | |
| NFKBIA |
2.0441 0.0170 | – | – | |
| NFRKB |
2.056 0.0292 | – | – | |
| TNFRSF1A |
2.5753 0.0015 | – | – | |
| CXCL8 | – | – |
0.0959 0.0422 | |
| LTA | – | – |
0.489 0.0157 | |
| JNK/p38 signalling | ELK1 |
2.9532 0.0012 |
2.2857 0.0128 |
2.4822 0.0054 |
| IL1B | – |
0.4534 0.0017 |
0.4067 0.0025 | |
| MAPK8IP3 |
2.0727 0.0129 | – | – | |
| JAK/STATsignalling | CCL2 | – | – | – |
| IFNG | – | – |
0.173 0.0006 | |
| IL2 | – | – | – | |
| Interferon regulatory factor signalling | CXCL10 | – | – | – |
| IFNB1 | – | – | – | |
| IFNG | – | – |
0.173 0.0006 | |
| IRF1 |
2.7619 0.0012 | – | – | |
| TBK1 | – | – |
0.4399 0.0013 | |
| Cytokine signalling | CCL2 | – | – | – |
| IL1B | – |
0.4534 0.0016 |
0.4067 0.0025 | |
| IRAK1 |
5.4967 0.0003 |
3.3386 0.0193 |
3.4884 0.0089 | |
| IRAK2 | – | – | – | |
| SIGIRR |
2.2314 0.0105 |
2.1148 0.0045 | – | |
| TNFRSF1A |
2.5753 0.0015 | – | – | |
| NF/IL6 pathway | PTGS2 |
0.4895 0.0038 | – |
0.1811 0.0002 |