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Table 2 List of differentially expressed genes of TLR signalling pathways between patients and healthy controls

From: Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure

Gene symbol Gene Neutrophils
C-LC D-LC ACLF
Fold change
P value
Fold change
P value
Fold change
P value
Toll like receptor TLR10
TLR3 0.4231
0.0478
0.2398
0.0016
TLR9 4.0564
0.0009
2.5115
0.03556
2.6805
0.023
SIGIRR 2.2314
0.0105
2.1148
0.0447
Effectors FADD 2.022
0.0302
2.2185
0.0133
IRAK1 5.4967
0.0003
3.3386
0.0193
3.4884
0.0089
IRAK2
Interacting proteins and adaptors CD14 2.1815
0.0116
2.3584
0.0033
HSPA1A 4.0346
0.0017
2.3591
0.0183
3.7515
0.0039
MAPK8IP3 2.0727
0.0129
TOLLIP 2.4367
0.0113
2.111
0.0039
TIRAP 2.4229
0.0012
Regulation of adaptive immunity IFNG 0.173
0.0006
IL10 2.6697
0.0249
IL12A
IL1B 0.4534
0.0017
0.4067
0.0025
IL2
Downstream pathway of toll like receptors
 NFKB signalling FADD 2.022
0.0302
2.2185
0.0133
IL10 2.6697
0.0249
IL1B 0.4534
0.0017
0.4067
0.0025
IRAK1 5.4967
0.0003
3.3386
0.0193
3.4884
0.0089
IRAK2
MAP4K4 2.0512
0.0018
NFKB2 2.2645
0.0060
NFKBIA 2.0441
0.0170
NFRKB 2.056
0.0292
TNFRSF1A 2.5753
0.0015
CXCL8 0.0959
0.0422
LTA 0.489
0.0157
 JNK/p38 signalling ELK1 2.9532
0.0012
2.2857
0.0128
2.4822
0.0054
IL1B 0.4534
0.0017
0.4067
0.0025
MAPK8IP3 2.0727
0.0129
 JAK/STATsignalling CCL2
IFNG 0.173
0.0006
IL2
 Interferon regulatory factor signalling CXCL10
IFNB1
IFNG 0.173
0.0006
IRF1 2.7619
0.0012
TBK1 0.4399
0.0013
 Cytokine signalling CCL2
IL1B 0.4534
0.0016
0.4067
0.0025
IRAK1 5.4967
0.0003
3.3386
0.0193
3.4884
0.0089
IRAK2
SIGIRR 2.2314
0.0105
2.1148
0.0045
TNFRSF1A 2.5753
0.0015
 NF/IL6 pathway PTGS2 0.4895
0.0038
0.1811
0.0002
  1. C-LC compensated liver cirrhosis, D-LC decompensated liver cirrhosis, ACLF acute-on-chronic liver failure