Fig. 2

Baseline quantitative sensory testing (QST) profile for patients in the mechanistic study (n = 19). A CDT: cold detection threshold; WDT: warm detection threshold; TSL: thermal sensory limen; CPT: cold pain threshold; HPT: heat pain threshold; PPT: pressure pain threshold; MPT: mechanical pain threshold; MPS: mechanical pain sensitivity; WUR: wind up ratio; MDT: mechanical detection threshold; VDT: vibration detection threshold. Data are presented as mean z-scores for thermal and mechanical QST parameters. Values greater than 0 represents a gain-of-function. Data less than 0 represent a loss-of-function. Dotted lines indicate 95% confidence interval for normative German network on neuropathic pain (DFNS) data for healthy controls. B Baseline dynamic mechanical allodynia (DMA) and paradoxical heat sensations (PHS) in patients in the mechanistic study (n = 19). Data are mean numeric pain ratings for DMA on a logarithmic scale (0–100) and frequency of PHS (0–3). Any score for DMA is considered as abnormal. A, B p =  ≤ 0.05*, p =  ≤ 0.01**, p =  ≤ 0.001*** denotes this level of significance compared to normative DFNS reference data