Fig. 5

Gene Set Enrichment Analysis (GSEA) to identify key function of ITK. A The correlativity analysis between ITK expression and the TCGA gene data set (Pearso’s correlation test, r > 0.3 or r < 0.3 as threshold value), B The positive correlation genes (CD244 p = 9.1e−10, SOCS1 p = 4.8e−09) and negative correlation (SMARCD1 p = 0.0045) (t test). C The pathways analysis of the high correlated genes. D, E the cumulative distribution function analysis with high ITK level and low ITK level respectively