DEL in China: the D antigen among serologic RhD-negative individuals

Table 4 Asian type DEL (RHDDEL1*) in serologic RhD-negative Han who tested positive in adsorption-elution method

Regions	Province/city	RhD-negative individuals (n)		Allele identification (n)						References
		RhD-negative individuals (n)		G1227A PCR-SSP		Sequencing		RHDDEL1* frequency among		References
		Total	Adsorption-elution positive	Neg	Pos	RHDDEL1*	Others	Adsorption-elution positive^a	Rh-negative^b
Eastern China	Shanghai	1585	279	11	268	268	11	96.1%	16.9%	[28]
	Shanghai	441	72	4	68	0	4	94.4%	15.4%	[39]
	Shandong	74	22	0	22	ND	ND	100%	29.7%	[40]
Northeastern China	Heilongjiang	374	62	1	61	0	1	98.4%	16.3%	[41]
Southeastern China	Zhejiang, Jiangsu	643	155	0	155	ND	ND	100%	24.1%	[42]
	Jiangsu,Guangdong, Guangxi	165	41	4	37	0	4	90.2%	22.4%	[29]
	Guangdong	102	26	0	26	25	1	96.2%	24.5%	[17]
Central China	Anhui	808	178	10	168	0	10	94.4%	20.8%	[30]
	Anhui	515	142	12	130	0	12	91.5%	25.2%	[43]
	Anhui	155	31	ND	ND	31	0	100%	20.0%	[18]
Taiwan	N/A	395	126	0	126	ND	ND	100%	31.9%	[44]
	N/A	294	94	0	94	94	0	100%	32.0%	[45]
	N/A	118	38	0	38	38	0	100%	32.2%	[47]
Total		5669	1266	42	1193	456	43	96.7%^c	21.6%^c	N/A

ND not done, N/A not applicable
^aRHD*DEL1 allele frequency among adsorption-elution positive Han individuals: 97.3% ± 3.4% (mean ± SD) for the 13 studies, 90.2–100% (range)
^bRHD*DEL1 allele frequency among RhD-negative Han individuals: 24.0% ± 5.8% (mean ± SD) for the 13 studies, 15.4%—32.2% (range)
^cCalculation: (1193 + 31) / 1266 × 100% = 96.7% and (1193 + 31)/5669 × 100% = 21.6%

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