Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Table 4 Relationships between sex hormones and bone turnover in linear regression

Bone turnover	Osteocalcin			β-crossLaps			PTH			25(OH)D
Sex hormones	β coefficient (95% CI)	R²	P-value	β coefficient (95% CI)	R²	P-value	β coefficient (95% CI)	R²	P-value	β coefficient (95% CI)	R²	P-value
LH (mIU/mL)	0.006 (0.004–0.009)	0.103	< 0.001	0.008 (0.004–0.011)	0.167	< 0.001	0.003 (0.001–0.006)	0.059	0.012	− 0.003 (− 0.004 to 0.001)	0.027	0.008
FSH (IU/L)	0.002 (0.001–0.003)	0.079	0.002	0.003 (0.002–0.005)	0.163	< 0.001	0.002 (0.001–0.003)	0.065	0.001	− 0.001 (− 0.002 to 0.000)	0.021	0.172
Testosterone (nmol/L)	0.031 (− 0.017 to 0.079)	0.068	0.202	0.000 (− 0.066 to 0.065)	0.141	0.991	0.026 (− 0.025 to 0.077)	0.052	0.313	0.022 (− 0.017 to 0.061)	0.020	0.268
Prolactin (μg/L)	− 0.001 (− 0.003 to 0.001)	0.067	0.373	0.002 (− 0.001 to 0.005)	0.143	0.181	0.000 (− 0.002 to 0.003)	0.051	0.902	− 0.001 (− 0.003 to 0.001)	0.020	0.192
Progesterone (nmol/L)	0.124 (0.062–0.185)	0.086	< 0.001	0.095 (0.011–0.179)	0.147	0.027	0.014 (− 0.052 to 0.080)	0.051	0.670	− 0.044 (− 0.094 to 0.006)	0.022	0.083
Estradiol (pmol/L)	0.001 (− 0.001 to 0.002)	0.067	0.405	0.003 (0.001–0.005)	0.155	0.001	0.001 (0.000–0.002)	0.053	0.178	− 0.002 (− 0.003 to 0.001)	0.043	< 0.001

PTH parathyroid hormone, 25(OH)D 25-hydroxyvitamin-D3, CI confidential interval, LH luteinizing hormone, FSH follicle-stimulating hormone

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