Regional brain tissue changes in patients with cystic fibrosis

Table 2 Regional brain gray matter density (mean ± SE, mm³/voxel) of CF patients and control corrected for age and sex

Brain areas	CF (n = 5)	Controls (n = 15)	p-values
Brain areas	Mean ± SE (95% confidence interval)	Mean ± SE (95% confidence interval)	p-values
L Prefr Cor	0.44 ± 0.013 (0.42–0.47)	0.38 ± 0.007 (0.37–0.40)	0.001
R Prefr Cor	0.47 ± 0.012 (0.44–0.49)	0.41 ± 0.007 (0.40–0.43)	0.001
R Vent Med Prefr Cor	0.57 ± 0.012 (0.54–0.59)	0.52 ± 0.006 (0.50–0.53)	0.002
L basal forebrain	0.49 ± 0.011 (0.47–0.52)	0.44 ± 0.006 (0.42–0.45)	< 0.001
R basal forebrain	0.45 ± 0.012 (0.43–0.48)	0.39 ± 0.007 (0.38–0.41)	0.001
R amygdala	0.38 ± 0.009 (0.36–0.40)	0.34 ± 0.005 (0.33–0.35)	0.001
R hippocampus	0.71 ± 0.006 (0.70–0.72)	0.68 ± 0.003 (0.68–0.69)	0.002
R parahippocampus	0.59 ± 0.007 (0.57–0.60)	0.55 ± 0.004 (0.54–0.56)	< 0.001
R cerebellar Cor	0.75 ± 0.010 (0.73–0.77)	0.70 ± 0.005 (0.69–0.71)	0.001
L insula	0.63 ± 0.015 (0.60–0.66)	0.56 ± 0.008 (0.55–0.58)	0.001
R insula	0.61 ± 0.013 (0.59–0.64)	0.55 ± 0.007 (0.54–0.57)	0.001
L mid frontal Cor	0.60 ± 0.007 (0.58–0.61)	0.55 ± 0.004 (0.55–0.56)	< 0.001
L sup frontal Cor	0.62 ± 0.011 (0.60–0.64)	0.57 ± 0.006 (0.55–0.58)	0.001
L sup parietal Cor	0.69 ± 0.019 (0.65–0.73)	0.61 ± 0.010 (0.58–0.63)	0.002
R sup parietal Cor	0.59 ± 0.016 (0.56–0.63)	0.51 ± 0.009 (0.49–0.53)	0.001
R sup temp Cor	0.67 ± 0.008 (0.65–0.69)	0.63 ± 0.005 (0.62–0.64)	0.001

CF cystic fibrosis, SE standard error, L left, Prefr prefrontal, Cor cortex, R right, Vent ventral, Med medial, Mid middle, Sup superior, Temp temporal

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