Fig. 1

FAM83A is overexpressed and related to tumor size, lymph node metastasis and clinical tumor stages in HNSCC. A Negative FAM83A expression in HNSCC adjacent normal tissues (A1, 100 × ; A2, 200 ×). B Low FAM83A expression in HNSCC tumor tissues (B1, 100 × ; B2, 200 ×). C High FAM83A expression in HNSCC tumor tissues (C1, 100 × ; C2, 200 ×). D Quantification analysis of FAM83A staining in HNSCC with different tumor size in microarrays. E Quantification analysis of FAM83A staining in HNSCC with different lymph node metastasis in microarrays. F Quantification analysis of FAM83A staining in HNSCC with different clinical tumor stages in microarrays. G Quantification analysis of FAM83A staining in HNSCC with different pathological classifications in microarrays. H The relative expression of FAM83A mRNA was measured by qRT-PCR in 48 freshly collected HNSCC samples and paired adjacent non-tumor tissues. The height of column represents the fold change (log2-transformed) in FAM83A expression in these 48 patients (right panel). I Differential expressions of FAM83A in HNSCC (n = 519) and normal tissues (n = 44) from the TCGA database. J The expressions of FAM83A protein in eight HNSCC tissue and matched adjacent normal tissues. K The expressions of FAM83A protein in HOK and HNSCC cell lines. *p < 0.05, **p < 0.01, ***p < 0.001