The role of PDGFRA as a therapeutic target in young colorectal cancer patients

Table 2 Upregulated oncogenes and tumor suppressor genes in young CRC

Gene	Fold change	q-value	Cancer associated	Full Name
WNT11	4.33	0.012	Suppressor gene	Wnt family member 11
HSPB7	3.28	0.023	Suppressor gene	Heat shock protein family B (small) member 7
FBLN1	3.14	0.001	Suppressor gene	Fibulin 1
CNN1	2.94	0.037	Suppressor gene	Calponin 1
CENPW	2.34	0.021	Oncogene	Centromere protein W
LCK	2.3	0.032	Oncogene	LCK proto-oncogene, Src family tyrosine kinase
CLU	2.24	0.01	Suppressor gene	Clusterin
AQP1	2.23	0.033	Oncogene	Aquaporin 1
S100A4	2.22	0.019	Oncogene	S100 calcium binding protein A4
TAGLN	2.22	0.031	Suppressor gene	Transgelin
GREM1	2.18	0.01	Oncogene	Gremlin 1, DAN family BMP antagonist
PDGFRA	2.18	0.001	Oncogene	Platelet derived growth factor receptor alpha
MMP12	2.18	0.028	Oncogene	Matrix metallopeptidase 12
SMO	2	0.028	Oncogene	Smoothened, frizzled class receptor

ISSN: 1479-5876