Fig. 3

Changes in volume and perfusion parameters and laboratory data during hemorrhage shock and resuscitation. A Blood withdrawn induced the decrements in central venous pressure (Friedman test, P = 0.011), pulmonary artery wedge pressure (RM ANOVA, F = 18.41, P = 0.001), and global end-diastolic blood volume (RM ANOVA, F = 22.79, P = 0.0002). These alterations were recovered by blood transfusions. B Blood withdrawn induced the increments in stroke volume variation (Freidman test, P = 0.0001), pulse pressure variation (RM ANOVA, F = 21.01, P = 0.0002), and pleth variability index (RM ANOVA, F = 13.23, P = 0.003). These alterations were recovered by blood transfusions. C Blood withdrawal and transfusions affected hemoglobin (RM ANOVA, F = 12.85, P = 0.0003) and lactate levels (Freidman test, P < 0.0001). D Blood withdrawal and transfusions affected cardiac function index (RM ANOVA, F = 7.13, P = 0.011) and cardiac power output (Freidman test, P < 0.0001). Data are presented as the mean ± standard error of the mean. *P < 0.05, †P < 0.01, $P < 0.001 vs. baseline. BL, baseline; BW10, 10 mL/kg of blood withdrawal; BW20, 20 mL/kg of blood withdrawal; BW30, 30 mL/kg of blood withdrawal; BT10, 10 mL/kg of blood transfusion; BT20, 20 mL/kg of blood transfusion; BT30, 30 mL/kg of blood transfusion