Table 2 Univariate and multivariate Cox analyses of overall survival prediction, based on IRF scores calculated by cases from TCGA
Variable | Univariate Cox analysis | Multivariate Cox analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (≥ 60 vs. < 60) | 1.73 (1.09–2.77) | 0.020 | 1.42 (0.86–2.33) | 0.171 |
Gender (male vs. female) | 1.08 (0.74–1.56) | 0.678 | 0.69 (0.47–1.04) | 0.075 |
T stage (T3 and T4 vs. T1 and T2) | 3.08 (1.50–6.33) | 0.002 | 1.23 (0.59–2.57) | 0.584 |
N stage (N1 and N2 vs. N0) | 2.82 (1.93–4.14) |  < 0.001 | 0.64 (0.25–1.62) | 0.341 |
M stage (M1 and MX vs. M0) | 2.86 (1.98–4.15) |  < 0.001 | 1.83 (1.18–2.82) | 0.006 |
Stage (III + IV vs. I + II) | 3.22 (2.18–4.77) |  < 0.001 | 2.77 (0.99–7.76) | 0.052 |
IRF score (high vs. low) | 2216.68 (654.36–7509.12) |  < 0.00 | 2401.99 (624.22–9242.82) |  < 0.001 |