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Table 2 Univariate and multivariate Cox analyses of overall survival prediction, based on IRF scores calculated by cases from TCGA

From: Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer

Variable Univariate Cox analysis Multivariate Cox analysis
HR (95% CI) P value HR (95% CI) P value
Age (≥ 60 vs. < 60) 1.73 (1.09–2.77) 0.020 1.42 (0.86–2.33) 0.171
Gender (male vs. female) 1.08 (0.74–1.56) 0.678 0.69 (0.47–1.04) 0.075
T stage (T3 and T4 vs. T1 and T2) 3.08 (1.50–6.33) 0.002 1.23 (0.59–2.57) 0.584
N stage (N1 and N2 vs. N0) 2.82 (1.93–4.14)  < 0.001 0.64 (0.25–1.62) 0.341
M stage (M1 and MX vs. M0) 2.86 (1.98–4.15)  < 0.001 1.83 (1.18–2.82) 0.006
Stage (III + IV vs. I + II) 3.22 (2.18–4.77)  < 0.001 2.77 (0.99–7.76) 0.052
IRF score (high vs. low) 2216.68 (654.36–7509.12)  < 0.00 2401.99 (624.22–9242.82)  < 0.001
  1. HR hazard ratio, CI confidence interval