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Table 1 Gene ontology analysis of differentially expressed genes associated with pancreatic cancer

From: GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments

Expression

Category

Term

Gene count

%

P value

Up-regulated

GOTERM_BP_DIRECT

GO:0030198 ~ extracellular matrix organization

35

8.10

4.85E−20

GOTERM_BP_DIRECT

GO:0060337 ~ type I interferon signaling pathway

16

3.70

1.72E−11

GOTERM_BP_DIRECT

GO:0030574 ~ collagen catabolic process

16

3.70

1.72E−11

GOTERM_BP_DIRECT

GO:0007155 ~ cell adhesion

39

9.03

1.88E−11

GOTERM_BP_DIRECT

GO:0051607 ~ defense response to virus

22

5.09

3.53E−10

GOTERM_MF_DIRECT

GO:0005509 ~ calcium ion binding

48

11.11

9.05E−11

GOTERM_MF_DIRECT

GO:0005518 ~ collagen binding

14

3.24

7.95E−10

GOTERM_MF_DIRECT

GO:0008201 ~ heparin binding

19

4.40

3.00E−08

GOTERM_MF_DIRECT

GO:0005178 ~ integrin binding

15

3.47

1.25E−07

GOTERM_MF_DIRECT

GO:0005201 ~ extracellular matrix structural constituent

12

2.78

3.33E−07

GOTERM_CC_DIRECT

GO:0005576 ~ extracellular region

111

25.69

3.52E−26

GOTERM_CC_DIRECT

GO:0005615 ~ extracellular space

95

21.99

7.82E−23

GOTERM_CC_DIRECT

GO:0070062 ~ extracellular exosome

143

33.10

2.98E−21

GOTERM_CC_DIRECT

GO:0031012 ~ extracellular matrix

42

9.72

1.88E−20

GOTERM_CC_DIRECT

GO:0005578 ~ proteinaceous extracellular matrix

33

7.64

2.75E−14

Down-regulated

GOTERM_BP_DIRECT

GO:0072593 ~ reactive oxygen species metabolic process

6

3.39

1.84E−05

GOTERM_BP_DIRECT

GO:0008652 ~ cellular amino acid biosynthetic process

5

2.82

9.84E−05

GOTERM_BP_DIRECT

GO:0006520 ~ cellular amino acid metabolic process

5

2.82

5.42E−04

GOTERM_BP_DIRECT

GO:0071294 ~ cellular response to zinc ion

4

2.26

7.22E−04

GOTERM_BP_DIRECT

GO:0006508 ~ proteolysis

14

7.91

9.58E−04

GOTERM_MF_DIRECT

GO:0030170 ~ pyridoxal phosphate binding

8

4.52

1.43E−06

GOTERM_MF_DIRECT

GO:0005385 ~ zinc ion transmembrane transporter activity

4

2.26

1.28E−03

GOTERM_MF_DIRECT

GO:0019899 ~ enzyme binding

11

6.21

1.80E−03

GOTERM_MF_DIRECT

GO:0004435 ~ phosphatidylinositol phospholipase C activity

4

2.26

2.34E−03

GOTERM_MF_DIRECT

GO:0042803 ~ protein homodimerization activity

17

9.60

2.43E−03

GOTERM_CC_DIRECT

GO:0070062 ~ extracellular exosome

55

31.07

8.36E−08

GOTERM_CC_DIRECT

GO:0005615 ~ extracellular space

29

16.38

5.61E−05

GOTERM_CC_DIRECT

GO:0016323 ~ basolateral plasma membrane

8

4.52

1.57E−03

GOTERM_CC_DIRECT

GO:0005887 ~ integral component of plasma membrane

25

14.12

3.38E−03

GOTERM_CC_DIRECT

GO:0005576 ~ extracellular region

27

15.25

4.39E−03

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Journal of Translational Medicine

ISSN: 1479-5876

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