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Table 1 Gene ontology analysis of differentially expressed genes associated with pancreatic cancer

From: GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments

Expression Category Term Gene count % P value
Up-regulated GOTERM_BP_DIRECT GO:0030198 ~ extracellular matrix organization 35 8.10 4.85E−20
GOTERM_BP_DIRECT GO:0060337 ~ type I interferon signaling pathway 16 3.70 1.72E−11
GOTERM_BP_DIRECT GO:0030574 ~ collagen catabolic process 16 3.70 1.72E−11
GOTERM_BP_DIRECT GO:0007155 ~ cell adhesion 39 9.03 1.88E−11
GOTERM_BP_DIRECT GO:0051607 ~ defense response to virus 22 5.09 3.53E−10
GOTERM_MF_DIRECT GO:0005509 ~ calcium ion binding 48 11.11 9.05E−11
GOTERM_MF_DIRECT GO:0005518 ~ collagen binding 14 3.24 7.95E−10
GOTERM_MF_DIRECT GO:0008201 ~ heparin binding 19 4.40 3.00E−08
GOTERM_MF_DIRECT GO:0005178 ~ integrin binding 15 3.47 1.25E−07
GOTERM_MF_DIRECT GO:0005201 ~ extracellular matrix structural constituent 12 2.78 3.33E−07
GOTERM_CC_DIRECT GO:0005576 ~ extracellular region 111 25.69 3.52E−26
GOTERM_CC_DIRECT GO:0005615 ~ extracellular space 95 21.99 7.82E−23
GOTERM_CC_DIRECT GO:0070062 ~ extracellular exosome 143 33.10 2.98E−21
GOTERM_CC_DIRECT GO:0031012 ~ extracellular matrix 42 9.72 1.88E−20
GOTERM_CC_DIRECT GO:0005578 ~ proteinaceous extracellular matrix 33 7.64 2.75E−14
Down-regulated GOTERM_BP_DIRECT GO:0072593 ~ reactive oxygen species metabolic process 6 3.39 1.84E−05
GOTERM_BP_DIRECT GO:0008652 ~ cellular amino acid biosynthetic process 5 2.82 9.84E−05
GOTERM_BP_DIRECT GO:0006520 ~ cellular amino acid metabolic process 5 2.82 5.42E−04
GOTERM_BP_DIRECT GO:0071294 ~ cellular response to zinc ion 4 2.26 7.22E−04
GOTERM_BP_DIRECT GO:0006508 ~ proteolysis 14 7.91 9.58E−04
GOTERM_MF_DIRECT GO:0030170 ~ pyridoxal phosphate binding 8 4.52 1.43E−06
GOTERM_MF_DIRECT GO:0005385 ~ zinc ion transmembrane transporter activity 4 2.26 1.28E−03
GOTERM_MF_DIRECT GO:0019899 ~ enzyme binding 11 6.21 1.80E−03
GOTERM_MF_DIRECT GO:0004435 ~ phosphatidylinositol phospholipase C activity 4 2.26 2.34E−03
GOTERM_MF_DIRECT GO:0042803 ~ protein homodimerization activity 17 9.60 2.43E−03
GOTERM_CC_DIRECT GO:0070062 ~ extracellular exosome 55 31.07 8.36E−08
GOTERM_CC_DIRECT GO:0005615 ~ extracellular space 29 16.38 5.61E−05
GOTERM_CC_DIRECT GO:0016323 ~ basolateral plasma membrane 8 4.52 1.57E−03
GOTERM_CC_DIRECT GO:0005887 ~ integral component of plasma membrane 25 14.12 3.38E−03
GOTERM_CC_DIRECT GO:0005576 ~ extracellular region 27 15.25 4.39E−03