Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates

Table 1 Associations of Immunotype Scores and immune cell homing (ICH) gene expression levels for tumor subsets. Correlation coefficients (r values) calculated by the Spearman rank test. PTPRC gene used to represent CD45⁺ immune cells for comparison

	N (%)	PTPRC (CD45)		CXCL9		CCL5		CXCL13
	N (%)	r value (95% CI)	p value	r value (95% CI)	p value	r value (95% CI)	p value	r value (95% CI)	p value
All Tumors	119	0.32 (0.14–0.47)	0.0005	0.53 (0.38–0.65)	< 0.0001	0.52 (0.37–0.64)	< 0.0001	0.44 (0.28–0.58)	< 0.0001
Tumor type
Primary	7 (6%)	− 0.39	0.38	0.77	0.06	0.56	0.2	0.17	0.73
Metastatic	112 (94%)	0.32 (0.14–0.48)	0.0006	0.52 (0.36–0.65)	< 0.0001	0.51 (0.36–0.64)	< 0.0001	0.46 (0.29–0.6)	< 0.0001
Metastatic sites
Skin/subcutaneous	64 (57%)	0.22 (− 0.04–0.45)	0.08	0.52 (0.3–0.68)	< 0.0001	0.58 (0.38–0.72)	< 0.0001	0.42 (0.19–0.61)	0.0005
Lymph Node	41 (37%)	0.39 (0.08–0.63)	0.01	0.46 (0.16–0.68)	0.003	0.4 (0.1–0.64)	0.009	0.48 (0.19–0.69)	0.001
Abdomen	7 (6%)	0.54	0.21	0.62	0.15	0.84	0.024	0.62	0.15
Tumors with heterogeneity in immune infiltrates
Heterogenous TMA Cores	7 (42%)	0.48 (0.23–0.68)	0.0004	0.52 (0.27–0.7)	0.0001	0.55 (0.31–0.72)	< 0.0001	0.45 (0.18–0.65)	0.001

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