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Table 1 Associations of Immunotype Scores and immune cell homing (ICH) gene expression levels for tumor subsets. Correlation coefficients (r values) calculated by the Spearman rank test. PTPRC gene used to represent CD45+ immune cells for comparison

From: Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates

  N (%) PTPRC (CD45) CXCL9 CCL5 CXCL13
r value (95% CI) p value r value (95% CI) p value r value (95% CI) p value r value (95% CI) p value
All Tumors 119 0.32 (0.14–0.47) 0.0005 0.53 (0.38–0.65)  < 0.0001 0.52 (0.37–0.64)  < 0.0001 0.44 (0.28–0.58)  < 0.0001
Tumor type
 Primary 7 (6%) − 0.39 0.38 0.77 0.06 0.56 0.2 0.17 0.73
 Metastatic 112 (94%) 0.32 (0.14–0.48) 0.0006 0.52 (0.36–0.65)  < 0.0001 0.51 (0.36–0.64)  < 0.0001 0.46 (0.29–0.6)  < 0.0001
Metastatic sites
 Skin/subcutaneous 64 (57%) 0.22 (− 0.04–0.45) 0.08 0.52 (0.3–0.68)  < 0.0001 0.58 (0.38–0.72)  < 0.0001 0.42 (0.19–0.61) 0.0005
 Lymph Node 41 (37%) 0.39 (0.08–0.63) 0.01 0.46 (0.16–0.68) 0.003 0.4 (0.1–0.64) 0.009 0.48 (0.19–0.69) 0.001
 Abdomen 7 (6%) 0.54 0.21 0.62 0.15 0.84 0.024 0.62 0.15
Tumors with heterogeneity in immune infiltrates
 Heterogenous TMA Cores 7 (42%) 0.48 (0.23–0.68) 0.0004 0.52 (0.27–0.7) 0.0001 0.55 (0.31–0.72)  < 0.0001 0.45 (0.18–0.65) 0.001
  1. 95% CI 95% confidence interval, TMA tissue microarray