Table 1 Associations of Immunotype Scores and immune cell homing (ICH) gene expression levels for tumor subsets. Correlation coefficients (r values) calculated by the Spearman rank test. PTPRC gene used to represent CD45+ immune cells for comparison
| Â | N (%) | PTPRC (CD45) | CXCL9 | CCL5 | CXCL13 | ||||
|---|---|---|---|---|---|---|---|---|---|
r value (95% CI) | p value | r value (95% CI) | p value | r value (95% CI) | p value | r value (95% CI) | p value | ||
All Tumors | 119 | 0.32 (0.14–0.47) | 0.0005 | 0.53 (0.38–0.65) |  < 0.0001 | 0.52 (0.37–0.64) |  < 0.0001 | 0.44 (0.28–0.58) |  < 0.0001 |
Tumor type | |||||||||
 Primary | 7 (6%) | − 0.39 | 0.38 | 0.77 | 0.06 | 0.56 | 0.2 | 0.17 | 0.73 |
 Metastatic | 112 (94%) | 0.32 (0.14–0.48) | 0.0006 | 0.52 (0.36–0.65) |  < 0.0001 | 0.51 (0.36–0.64) |  < 0.0001 | 0.46 (0.29–0.6) |  < 0.0001 |
Metastatic sites | |||||||||
 Skin/subcutaneous | 64 (57%) | 0.22 (− 0.04–0.45) | 0.08 | 0.52 (0.3–0.68) |  < 0.0001 | 0.58 (0.38–0.72) |  < 0.0001 | 0.42 (0.19–0.61) | 0.0005 |
 Lymph Node | 41 (37%) | 0.39 (0.08–0.63) | 0.01 | 0.46 (0.16–0.68) | 0.003 | 0.4 (0.1–0.64) | 0.009 | 0.48 (0.19–0.69) | 0.001 |
 Abdomen | 7 (6%) | 0.54 | 0.21 | 0.62 | 0.15 | 0.84 | 0.024 | 0.62 | 0.15 |
Tumors with heterogeneity in immune infiltrates | |||||||||
 Heterogenous TMA Cores | 7 (42%) | 0.48 (0.23–0.68) | 0.0004 | 0.52 (0.27–0.7) | 0.0001 | 0.55 (0.31–0.72) |  < 0.0001 | 0.45 (0.18–0.65) | 0.001 |