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Table 5 Univariate and multivariate analyses of prognostic markers for overall survival in ESCC

From: SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Variable Univariate analysis Multivariate analysis
HR 95% CI P-value HR 95% CI P-value
Nuclear NRF2 expression    0.005    0.002
 High vs. low or no 1.802 1.191–2.729   1.908 1.256–2.899  
SLC7A11 expression    0.004    0.010
 Positive vs. negative 1.858 1.220–2.829   1.767 1.146–2.725  
Sex    0.019    0.022
 Male vs. Female 0.598 0.389–0.919   0.6 0.389–0.927  
Age (years)    0.067    
 ≤ 60 vs. > 60 1.583 0.969–2.584     
Alcohol abuse    0.200    
 Yes vs. No 1.318 0.864–2.011     
Smoking    0.444    
 Yes vs. No 1.172 0.781–1.758     
Location    0.002    0.002
 Upper vs. Middle/Lower 1.898 1.268–2.839   1.908 1.256–2.899  
Length (cm)    0.038    
 ≤ 4 vs. > 4 1.566 1.025–2.394     
T stage    0.007    
 T1–2 vs. T3–4 1.542 1.126–2.112     
Lymph node metastasis    0.001    
 N0–1 vs. N2–3 1.741 1.243–2.437     
Distant metastasis    0.004    
 M0 vs. M1 2.404 1.321–4.375     
TNM stage    0.001    
 I–II vs. III–IV 1.634 1.220–2.188     
Treatment strategy    0.606    
 CRT vs. RT 0.888 0.566–1.394     
  1. HR: Hazard ratio; CI: confidence interval
  2. *p < 0.05