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Table 5 Univariate and multivariate analyses of prognostic markers for overall survival in ESCC

From: SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

P-value

HR

95% CI

P-value

Nuclear NRF2 expression

  

0.005

  

0.002

 High vs. low or no

1.802

1.191–2.729

 

1.908

1.256–2.899

 

SLC7A11 expression

  

0.004

  

0.010

 Positive vs. negative

1.858

1.220–2.829

 

1.767

1.146–2.725

 

Sex

  

0.019

  

0.022

 Male vs. Female

0.598

0.389–0.919

 

0.6

0.389–0.927

 

Age (years)

  

0.067

   

 ≤ 60 vs. > 60

1.583

0.969–2.584

    

Alcohol abuse

  

0.200

   

 Yes vs. No

1.318

0.864–2.011

    

Smoking

  

0.444

   

 Yes vs. No

1.172

0.781–1.758

    

Location

  

0.002

  

0.002

 Upper vs. Middle/Lower

1.898

1.268–2.839

 

1.908

1.256–2.899

 

Length (cm)

  

0.038

   

 ≤ 4 vs. > 4

1.566

1.025–2.394

    

T stage

  

0.007

   

 T1–2 vs. T3–4

1.542

1.126–2.112

    

Lymph node metastasis

  

0.001

   

 N0–1 vs. N2–3

1.741

1.243–2.437

    

Distant metastasis

  

0.004

   

 M0 vs. M1

2.404

1.321–4.375

    

TNM stage

  

0.001

   

 I–II vs. III–IV

1.634

1.220–2.188

    

Treatment strategy

  

0.606

   

 CRT vs. RT

0.888

0.566–1.394

    
  1. HR: Hazard ratio; CI: confidence interval
  2. *p < 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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