Fig. 1

Workflow of the study. Clarification of mechanisms of HCC with CYP2D6*10 polymorphisms and screening of potential biomarkers using label-free global proteome analysis. CYP2D6, cytochrome P4502D6. CC and TT refer to CYP2D6*10 CC or TT genotype patients. ANGPTL6, angiopoietinâlike 6. AUC, area under the curve. BP, biological processes. GO, gene ontology. Con, control. RNA-seq, RNA sequencing. HCC, hepatocellular carcinoma. ELISA, enzyme-linked immunosorbent assay. WB, western blotting. IHC, immunohistochemistry