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Table 3 Clinic characteristics of validation cohort

From: Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy

 

Healthy control (n  =  16)

T2DM (n  =  15)

DN (n  =  28)

Males

8 (50%)

8 (53%)

14 (50%)

Age (years)

38 (25–58)

51.8 (40.5–67.6)

59 (51–69)

BMI (kg/m2)

22.1 (20.62–23.71)

25.69 (23.60–28.52) *

24.48 (22.12–27.99)*

Total cholesterol (g/L)

–

4.71 (4.19–5.67)

4.48 (3.68–6.89)

Triglyceride (mg/dL)

–

2.55 (1.59–3.97)

1.89 (1.47–2.32)

BUN (mmol/L)

4.15 (3.53–4.96)

5.99 (4.97–9.1)

12.3 (6.9–17.7)***##

SCr (μmol/L)

78 (68.25–89.5)

79 (68.4–111)

188 (99–254)**#

UA (μmol/L)

307 (274–341)

329 (294–387)

372 (318–495)

Plasma albumin (g/L)

45 (40–50)

42 (40–43)

30 (26.5–35.5)****####

eGFR (ml/min/1.73m2)

86.2 (78.7–97.3)

83.8 (60.2–99.5)

31.8 (18.7–73.6)*#

Urinary ACR (mg/g)

4 (0–28)

43 (2–159)

698 (399–1056)**##

  1. Values are expressed as median (IQR) (Mann–Whitney U test, *p  <  0.05, **p  <  0.01, ***p  <  0.001, ****p  <  0.0001 compared with healthy controls; #p  <  0.05, ##p  <  0.01, ####p  <  0.0001 compared with T2DM)