| |
Healthy control (n = 16)
|
T2DM (n = 15)
|
DN (n = 28)
|
|---|
|
Males
|
8 (50%)
|
8 (53%)
|
14 (50%)
|
|
Age (years)
|
38 (25–58)
|
51.8 (40.5–67.6)
|
59 (51–69)
|
|
BMI (kg/m2)
|
22.1 (20.62–23.71)
|
25.69 (23.60–28.52) *
|
24.48 (22.12–27.99)*
|
|
Total cholesterol (g/L)
|
–
|
4.71 (4.19–5.67)
|
4.48 (3.68–6.89)
|
|
Triglyceride (mg/dL)
|
–
|
2.55 (1.59–3.97)
|
1.89 (1.47–2.32)
|
|
BUN (mmol/L)
|
4.15 (3.53–4.96)
|
5.99 (4.97–9.1)
|
12.3 (6.9–17.7)***##
|
|
SCr (μmol/L)
|
78 (68.25–89.5)
|
79 (68.4–111)
|
188 (99–254)**#
|
|
UA (μmol/L)
|
307 (274–341)
|
329 (294–387)
|
372 (318–495)
|
|
Plasma albumin (g/L)
|
45 (40–50)
|
42 (40–43)
|
30 (26.5–35.5)****####
|
|
eGFR (ml/min/1.73m2)
|
86.2 (78.7–97.3)
|
83.8 (60.2–99.5)
|
31.8 (18.7–73.6)*#
|
|
Urinary ACR (mg/g)
|
4 (0–28)
|
43 (2–159)
|
698 (399–1056)**##
|
- Values are expressed as median (IQR) (Mann–Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with healthy controls; #p < 0.05, ##p < 0.01, ####p < 0.0001 compared with T2DM)
