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Table 3 Performance metrics of biomarker-based models

From: Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

Metrics

pCR-score-based

sTILs-baseda

Subtype-baseda

Baselinea

Integratedb

Mean (95% CI)

P

Mean (95% CI)

P

Mean (95% CI)

P

Mean (95% CI)

P

Mean (95% CI)

P

F1 score

0.503 (0.424–0.581)

–

0.250 (0.181–0.320)

< 0.001

0.386 (0.252–0.519)

0.100

0.565 (0.491–0.639)

0.196

0.682 (0.631–0.732)

0.002

Accuracy

0.853 (0.827–0.879)

–

0.810 (0.786–0.834)

< 0.001

0.815 (0.785–0.846)

0.008

0.840 (0.808–0.873)

0.380

0.884 (0.859–0.909)

< 0.001

AUC

0.822 (0.784–0.861)

–

0.780 (0.753–0.806)

< 0.001

0.818 (0.782–0.855)

0.858

0.839 (0.812–0.866)

0.485

0.890 (0.863–0.916)

0.001

Sensitivity

0.396 (0.314–0.474)

–

0.173 (0.118–0.226)

< 0.001

0.370 (0.230–0.511)

0.730

0.541 (0.433–0.648)

0.026

0.633 (0.552–0.715)

< 0.001

PPV

0.781 (0.699–0.864)

–

0.494 (0.377–0.612)

< 0.001

0.418 (0.278–0.559)

< 0.001

0.686 (0.571–0.801)

0.424

0.785 (0.707–0.863)

0.022

Specificity

0.971 (0.959–0.984)

–

0.969 (0.961–0.978)

1.000

0.936 (0.912–0.960)

0.057

0.918 (0.876–0.961)

0.092

0.945 (0.924–0.973)

0.180

NPV

0.864 (0.835–0.893)

–

0.823 (0.798–0.851)

< 0.001

0.855 (0.815–0.895)

0.472

0.889 (0.857–0.922)

0.070

0.910 (0.884–0.936)

0.144

TP

3.250 (2.590–3.910)

–

1.438 (1.004–1.871)

< 0.001

2.875 (1.794–3.956)

0.791

4.500 (3.527–5.473)

0.092

5.313 (4.517–6.108)

0.021

FN

5.313 (4.118–6.508)

–

7.125 (5.993–8.258)

< 0.001

5.688 (3.897–7.478)

0.791

4.063 (2.780–5.345)

0.092

3.250 (2.287–4.213)

0.021

FP

1.000 (0.565–1.435)

–

1.063 (0.757–1.368)

1.000

2.250 (1.413–3.087)

0.057

2.813 (1.367–4.258)

0.092

1.750 (0.936–2.564)

0.180

TN

33.44 (32.41–34.47)

–

33.38 (32.29–34.46)

1.000

32.19 (31.14–33.29)

0.057

31.63 (29.84–33.41)

0.092

32.69 (31.24–34.14)

0.180

  1. Bold indicates statistical significance (P  <  0.05)
  2. pCR pathological complete response; sTILs stromal tumor-infiltrating lymphocytes; OR odds ratio; CI confidence interval; AUC area under the curve
  3. aP value was from that the comparisons with pCRscore-based model
  4. bsolely refers to the P value was from the comparisons of baseline model and integrated model (baseline: sTILs  +  subtype; integrated: sTILs  +  subtype  +  pCR-score)
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Journal of Translational Medicine

ISSN: 1479-5876

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