Fig. 2

Knockdown of FGF11 inhibits NSCLC cell proliferation and promotes cell apoptosis. Cells were infected with lentivirus carrying FGF11 shRNA (shFGF11) or control shRNA (sh-NC). A qPCR analysis of FGF11 mRNA expression in A549 and NCI-H460 cells after shRNA introduction. B Western blot analysis of FGF11 protein levels in A549 and NCI-H460 cells. C The proliferation of A549 and NCI-H460 cells after shRNA introduction was detected by CCK-8 assay. D Colony formation assay of A549 and NCI-H460 cells after shRNA introduction. E Flow cytometry analysis of cells stained with Annexin-V and 7-AAD. Data are the summary of the measurements of 3 independent experiments (mean ± standard deviation). *P < 0.05, ** P < 0.01, ***P < 0.005 vs. sh-NC or empty vector-infected cells