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Table 5 Associations between multi-trajectory groups of lipid indices and incident CVD, heart failure, and all-cause mortality

From: Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies

Trajectory group Incident CVD Incident heart failure All-cause mortality
Cases/n (%) Hazard ratio (95% CI) p value Cases/n (%) Hazard ratio (95% CI) p value Cases/n (%) Hazard ratio (95% CI) p value
Group 1 239/3131 (7.6) 1.40 (1.08–1.82) 0.012 242/3099 (7.8) 1.16 (0.91–1.49) 0.230 521/3131 (16.6) 0.90 (0.77–1.05) 0.202
Group 2 344/2134 (16.1) 2.22 (1.72–2.87) < 0.001 270/2108 (12.8) 1.21 (0.95–1.55) 0.121 595/2134 (27.9) 1.02 (0.87–1.18) 0.819
Group 3 226/1991 (11.4) 1.84 (1.40–2.41) < 0.001 197/1962 (10.0) 1.26 (0.97–1.63) 0.087 387/1991 (19.4) 0.95 (0.87–1.19) 0.634
Group 4 81/1179 (6.9) 1.39 (1.01–1.87) 0.041 92/1169 (7.9) 1.17 (0.87–1.57) 0.296 179/1179 (15.2) 0.96 (0.81–1.14) 0.393
Group 5 75/1653 (4.5) 1.00 (Reference) 90/1637 (5.4) 1.00 (Reference) 247/1653 (14.9) 1.00 (Reference)
Group 6 51/765 (6.7) 1.45 (1.02–2.08) 0.040 61/755 (8.1) 1.50 (1.07–2.06) 0.018 145/765 (19.0) 1.21 (0.99–1.49) 0.068
Group 7 117/1276 (9.2) 1.56 (1.17–2.09) 0.003 123/1259 (9.8) 1.23 (0.94–1.62) 0.135 241/1276 (18.9) 0.90 (0.75–1.07) 0.228
  1. All the models were adjusted for age, sex, race, lipid-lowering medication use, diabetes mellitus, hypertension, body mass index, smoking status, and alcohol consumption at exam 4. The interaction of sex and trajectory groups was significant just for groups 1, 2, and 3 (p < 0.05) and not significant for others
  2. CI confidence interval, CVD cardiovascular disease