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Table 5 Associations between multi-trajectory groups of lipid indices and incident CVD, heart failure, and all-cause mortality

From: Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies

Trajectory group

Incident CVD

Incident heart failure

All-cause mortality

Cases/n (%)

Hazard ratio (95% CI)

p value

Cases/n (%)

Hazard ratio (95% CI)

p value

Cases/n (%)

Hazard ratio (95% CI)

p value

Group 1

239/3131 (7.6)

1.40 (1.08–1.82)

0.012

242/3099 (7.8)

1.16 (0.91–1.49)

0.230

521/3131 (16.6)

0.90 (0.77–1.05)

0.202

Group 2

344/2134 (16.1)

2.22 (1.72–2.87)

< 0.001

270/2108 (12.8)

1.21 (0.95–1.55)

0.121

595/2134 (27.9)

1.02 (0.87–1.18)

0.819

Group 3

226/1991 (11.4)

1.84 (1.40–2.41)

< 0.001

197/1962 (10.0)

1.26 (0.97–1.63)

0.087

387/1991 (19.4)

0.95 (0.87–1.19)

0.634

Group 4

81/1179 (6.9)

1.39 (1.01–1.87)

0.041

92/1169 (7.9)

1.17 (0.87–1.57)

0.296

179/1179 (15.2)

0.96 (0.81–1.14)

0.393

Group 5

75/1653 (4.5)

1.00 (Reference)

90/1637 (5.4)

1.00 (Reference)

247/1653 (14.9)

1.00 (Reference)

Group 6

51/765 (6.7)

1.45 (1.02–2.08)

0.040

61/755 (8.1)

1.50 (1.07–2.06)

0.018

145/765 (19.0)

1.21 (0.99–1.49)

0.068

Group 7

117/1276 (9.2)

1.56 (1.17–2.09)

0.003

123/1259 (9.8)

1.23 (0.94–1.62)

0.135

241/1276 (18.9)

0.90 (0.75–1.07)

0.228

  1. All the models were adjusted for age, sex, race, lipid-lowering medication use, diabetes mellitus, hypertension, body mass index, smoking status, and alcohol consumption at exam 4. The interaction of sex and trajectory groups was significant just for groups 1, 2, and 3 (p < 0.05) and not significant for others
  2. CI confidence interval, CVD cardiovascular disease