|
Trajectory group
|
Incident CVD
|
Incident heart failure
|
All-cause mortality
|
|---|
|
Cases/n (%)
|
Hazard ratio (95% CI)
|
p value
|
Cases/n (%)
|
Hazard ratio (95% CI)
|
p value
|
Cases/n (%)
|
Hazard ratio (95% CI)
|
p value
|
|---|
|
Group 1
|
239/3131 (7.6)
|
1.40 (1.08–1.82)
|
0.012
|
242/3099 (7.8)
|
1.16 (0.91–1.49)
|
0.230
|
521/3131 (16.6)
|
0.90 (0.77–1.05)
|
0.202
|
|
Group 2
|
344/2134 (16.1)
|
2.22 (1.72–2.87)
|
< 0.001
|
270/2108 (12.8)
|
1.21 (0.95–1.55)
|
0.121
|
595/2134 (27.9)
|
1.02 (0.87–1.18)
|
0.819
|
|
Group 3
|
226/1991 (11.4)
|
1.84 (1.40–2.41)
|
< 0.001
|
197/1962 (10.0)
|
1.26 (0.97–1.63)
|
0.087
|
387/1991 (19.4)
|
0.95 (0.87–1.19)
|
0.634
|
|
Group 4
|
81/1179 (6.9)
|
1.39 (1.01–1.87)
|
0.041
|
92/1169 (7.9)
|
1.17 (0.87–1.57)
|
0.296
|
179/1179 (15.2)
|
0.96 (0.81–1.14)
|
0.393
|
|
Group 5
|
75/1653 (4.5)
|
1.00 (Reference)
|
–
|
90/1637 (5.4)
|
1.00 (Reference)
|
–
|
247/1653 (14.9)
|
1.00 (Reference)
|
–
|
|
Group 6
|
51/765 (6.7)
|
1.45 (1.02–2.08)
|
0.040
|
61/755 (8.1)
|
1.50 (1.07–2.06)
|
0.018
|
145/765 (19.0)
|
1.21 (0.99–1.49)
|
0.068
|
|
Group 7
|
117/1276 (9.2)
|
1.56 (1.17–2.09)
|
0.003
|
123/1259 (9.8)
|
1.23 (0.94–1.62)
|
0.135
|
241/1276 (18.9)
|
0.90 (0.75–1.07)
|
0.228
|
- All the models were adjusted for age, sex, race, lipid-lowering medication use, diabetes mellitus, hypertension, body mass index, smoking status, and alcohol consumption at exam 4. The interaction of sex and trajectory groups was significant just for groups 1, 2, and 3 (p < 0.05) and not significant for others
- CI confidence interval, CVD cardiovascular disease
