Fig. 5
From: HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease
Asian populations contain a high diversity of MHC class I molecules that strongly bind the SARS-CoV-2 virus. A Unsupervised classification (Euclidean distances) of 69alleles of HLA-A, -B, or -C (all with prevalence higher than 0.01) based on their binding affinity for the SARS-CoV-2 immunopeptidome (three categories: strong 0–50 nM, regular 50–500 nM, weak 500–5000 nM). Color annotation depicts 7 allele clusters based on patterns of antigen presentation and 3 superclusters distinguished by proportions of strong presenters (low, medium, high). B Barplot of the prevalence of HLA clusters in populations from different world regions. C Barplot of supercluster representation among different types of HLA class-I alleles (A–C) and world regions