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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

Fig. 5

Asian populations contain a high diversity of MHC class I molecules that strongly bind the SARS-CoV-2 virus. A Unsupervised classification (Euclidean distances) of 69alleles of HLA-A, -B, or -C (all with prevalence higher than 0.01) based on their binding affinity for the SARS-CoV-2 immunopeptidome (three categories: strong 0–50 nM, regular 50–500 nM, weak 500–5000 nM). Color annotation depicts 7 allele clusters based on patterns of antigen presentation and 3 superclusters distinguished by proportions of strong presenters (low, medium, high). B Barplot of the prevalence of HLA clusters in populations from different world regions. C Barplot of supercluster representation among different types of HLA class-I alleles (AC) and world regions

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