Fig. 3

CHN1 interference inhibits the tumorigenicity of CC cells. a CHN1 expression was reduced after shRNA knockdown in both SiHa and HeLa cells. b Cell proliferation was inhibited after CHN1 knockdown in both cell lines (data represent means ± SD, n = 3, **p < 0.01). c Foci formation was inhibited after the interference of CHN1 expression in SiHa and Hela cells (data represent means ± SD, n = 3, **p < 0.01). d Smaller xenograft tumors were generated after the injection of SiHa-shCHN1 cells into nude mice. 5 × 10^7 CHN1-inhibited or empty vector transduced SiHa cells were used for in vivo detection, respectively. Tumors were harvested and assessed 8-week post xenograft (right, n = 5 for each group, **p < 0.01)