Nomogram for short-term outcome assessment in AChR subtype generalized myasthenia gravis

Table 3 Univariate and multivariate logistic regression models for minimal symptom expression in the development group

Variables	Subgroups	Univariate analysis			Multivariate analysis**
Variables	Subgroups	OR	95% CI	P value	OR	95% CI	P value
Gender	Male	1
	Female	0.5	0.19–1.25	0.146
Age at onset	EOMG	1
	LOMG	1.2	0.42–3.73	0.744
	Elderly-onset MG	0.76	0.18–3.90	0.713
MGFA classification	II	1
	III	1.19	0.44–3.45	0.741
	IV	0.57	0.09–4.58	0.553
Thymoma	Yes	1
	No	0.71	0.25–1.86	0.494
Thymectomy	No	1
	Yes	2.2	0.73–8.23	0.192
Worsening	Yes
	No	2.36	0.78–8.80	0.155
Autoimmune disease	No	1
	Yes	0.85	0.22–4.21	0.827
MMT score	> 26	1
	≤ 26	2.36	0.54–9.72	0.229
Anti-AChR Abs titer, nmol/L	> 9	1
	≤ 9	0.49	0.15–1.37	0.197
Duration, months	> 12	1			1
	≤ 12	4.41	1.73–11.90	0.002^**	3.45	1.23–10.24	0.021
Pyridostigmine dosage, mg/day	≤ 240
	> 240	0.46	0.10–2.50	0.339
MG-ADL score	> 3	1
	≤ 3	2.74	0.69–18.36	0.207
Bulbar score	≤ 1	1
	> 1	2.01	0.81–5.19	0.136
Respiratory function	Normal	1
	Abnormal	1.53	0.56–4.65	0.426
Limb score	≤ 1	1
	> 1	1.51	0.57–4.31	0.418
Ocular score	> 2				1
	≤ 2	2.87	1.11–8.15	0.036^**	6.00	1.82–24.58	0.006
QMG score	≤ 13	1			1
	> 13	2.36	0.78–8.80	0.155	11.95	2.31–95.82	0.008
Extraocular muscle score	≥ 1	1
	0	2.52	0.84–9.39	0.124
Bulbar muscle score	≥ 1	1
	0	0.51	0.17–1.37	0.198
Respiratory muscle score	≥ 80	1
	65–79	0.98	0.36–2.79
	50–64	0.75	0.28–9.48
	< 50	0.81	0.07–16.83
Gross motor score	> 9	1			1
	≤ 9	2.67	0.90–7.81	0.072^*	10.82	2.22–69.13	0.006
Axial motor score	> 2	1
	≤ 2	1.70	0.33–7.48	0.493

CI, confidence interval, OR odds ratio, MSE minimal symptom expression, EOMG early-onset myasthenia gravis, LOMG late-onset myasthenia gravis, MG myasthenia gravis, MGFA Myasthenia Gravis Foundation of America, AChR acetylcholine receptor, Abs antibodies, MMT manual muscle test, MG-ADL myasthenia gravis-activity of daily living, QMG quantitative myasthenia gravis
*Statistical significance (α = 0.1)
**Statistical significance (α = 0.05)

ISSN: 1479-5876