MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis

Table 1 Demographic of 103 nr-axSpA subjects with chronic inflammatory back pain and morning stiffness

	Age (yr)	Gender male (%)	BASDAI	ASDAS-CRP	ASDAS-ESR	Abnormal serum CRP (%)	Abnormal serum ESR (%)	SPARCC scores	Structural damage of MRI-SIJs
	Age (yr)	Gender male (%)	BASDAI	ASDAS-CRP	ASDAS-ESR	Abnormal serum CRP (%)	Abnormal serum ESR (%)	SPARCC scores	Sclerosis	Erosion	fJSW	DP^a	TP^b
Group 1 (n = 36)	31.3 ± 11.99	75%	2.47 ± 1.50	2.19 ± 0.66	1.90 ± 0.81	30.6%	33.3%	6.73 ± 7.73	77.8%	97.2%	44.4%	33.3%	30.6%
Group 2 (n = 22)	31.59 ± 12.51	86.4%	1.98 ± 0.82	1.86 ± 0.85	1.60 ± 0.60	22.7%	18.2%	NA	40.9%	100%	13.6%	27.3%	13.6%
Group 3 (n = 45)	30.09 ± 13.78	66.7%	2.36 ± 0.89	2.03 ± 0.59	1.73 ± 0.59	20%	24.4%	NA	51.1%	93.3%	8.9%	37.8%	8.9%
Group 1 + 2^c (n = 58)	31.41 ± 12.08	79.3%	2.28 ± 1.27	2.06 ± 0.75	1.79 ± 0.75	27.6%	27.6%	4.83 ± 6.85	63.8%	98.3%	32.8%	32.8%	31.0%
Group 1 + 2 + 3 (n = 103)	32.15 ± 12.81	73.8%	2.32 ± 1.12	2.05 ± 0.68	1.76 ± 0.68	24.3%	26.2%	2.49 ± 5.46	58.3%	96.1%	22.3%	35.0%	21.4%

BASDAI Bath Ankylosing Spondylitis Disease Activity Index, ASDAS Ankylosing Spondylitis Disease Activity Scores, CRP C-reactive protein, ESR erythrocyte sedimentation rate, BME bone marrow edema, MRI magnetic resonance imaging, SIJ sacroiliac joint, SPARCC Spondyloarthritis Research Consortium of Canada, fJSW focal joint space widening, ASAS Assessment of Spondyloarthritis international Society, nr-axSpA nonradiographic spondyloarthritis; Group 1, (MRI( +)/ mNY(−)); Group 2, [MRI(−)/ mNY(−)/ HLA-B27( +)]; Group 3, [MRI(−)/ mNY(-)/ HLA-B27(−)]; NA not applicable; ^aDP, double positive, dual presence of sclerosis and erosion on SIJ MRI; ^bTP, triple positive, simultaneous presence of sclerosis, erosion, and fJSW on MRI-SIJs; ^cgroup 1 + 2, ASAS defined nr-axSpA

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