Fig. 5
From: SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer
SRPK1 induced IκB phosphorylation dependent on AKT activation. a Western blotting analysis of the phosphorylation of IKKβ and IκBα of SW480 and HCT-116 cells overexpressing SRPK1 or vector only, and downregulated for SRPK1, or vector only. b Western blotting analysis the phosphorylation of AKT and IκBα of SW480 and HCT-116 cells overexpressing SRPK1, or vector only, under AKT inhibitor treatment. c A model of how SRPK1 enhances the anti-apoptosis ability of colon cancer via the NF-κB pathway by activating AKT. *p < 0.05, **p < 0.01, ***p < 0.001. SRPK1 Serine-arginine protein kinase 1, AKT protein kinase B, IκB inhibitor of nuclear factor kappa B, IKKβ IκB kinase beta subunit, IκBα IκB alpha subunit, NF-κB nuclear factor kappa B