Fig. 5

Circ_001209 regulates HRVEC function through targeting miR-15b-5p. A The relative expression of miR-15b-5p in HG-induced HRVECs was detected by qRT-PCR analysis. The expression level of COL12A1 in HG-induced HRVECs was detected by qRT-PCR analysis (B) and western blotting assay (C). D Wound healing assay was used to detect the invasion of HRVECs in different groups. H Transwell assay was used to detect the migration of HRVECs in different groups. I Tube formation experiment was performed to assess the tubule-forming ability of cells in different groups. E Transwell assay was used to detect the migration of HRVECs in different groups. F Tube formation experiment was performed to assess the tubule-forming ability of cells in different groups. The data was presented as mean ± SEM, n = 3 each group. Vs HG + ciR-NC group, *P < 0.05, **P < 0.01; vs HG + circ_001209 + mimics control group, ^#P < 0.05, ^##P < 0.01