Table 2 Univariable and multivariable Cox analyses of risk factors for RFS and multivariable Logistic analysis of risk factors for early-relapse in HCC patients with MVI who underwent R0 resection

Gender

 Male

237 (82.87%)

reference

 Female

49 (17.13%)

0.87

0.56–1.34

0.519

Age (years)

 ≤ 60

199 (69.58%)

reference

 > 60

87 (30.42%)

0.89

0.63–1.24

0.479

Hypertension

 Without

212 (74.13%)

reference

 With

74 (25.87%)

1.23

0.88–1.73

0.2305

Diabetes

 Without

240 (83.92%)

reference

 With

46 (16.08%)

0.96

0.63–1.46

0.8547

Coronary heart disease

 Without

275 (96.15%)

reference

 With

11 (3.85%)

1.15

0.54–2.46

0.7171

Smoking history

 Without

161 (56.29%)

reference

 With

125 (43.71%)

1.05

0.77–1.43

0.7508

Drinking history

 Without

198 (69.23%)

reference

 With

88 (30.77%)

0.96

0.69–1.33

0.802

Portal hypertension

 Without

221 (77.27%)

reference

 With

65 (22.73%)

1.27

0.89–1.81

0.1855

Preoperative Ln AFP level

4.62 ± 2.95

1.07

1.02–1.13

0.0081

1.05

1.00–1.11

1.12

1.02- 1.23

ALBI score

 ≤ − 2.60

256 (89.51%)

reference

reference

 > − 2.60 to ≤ − 1.39

30 (10.49%)

2.15

1.41–3.27

0.0004

1.94

1.10–3.43

2.04

0.86- 4.82

Preoperative PT (second)

11.92 ± 0.95

1.12

0.95–1.32

0.1671

Preoperative blood glucose level (mmol/L)

5.62 ± 1.72

1.05

0.96–1.16

0.276

Preoperative serum creatinine level (mg/dl)

73.35 ± 14.29

0.99

0.98–1.00

0.1635

Preoperative ALB (g/L)

44.02 ± 4.19

0.95

0.91–0.98

0.004

1.01

0.96–1.05

Preoperative ALT (U/L)

35.16 ± 23.38

1

1.00- 1.01

0.2086

Preoperative AST (U/L)

34.68 ± 22.96

1.01

1.00- 1.01

0.006

1

1.00–1.01

Preoperative HBsAg

 Positive

232 (81.12%)

reference

 Negative

54 (18.88%)

1.08

0.74–1.58

0.692

Preoperative HBeAg

 Negative

221 (77.27%)

reference

reference

 Positive

65 (22.73%)

1.43

1.01–2.02

0.0454

1.52

1.04–2.20

1.93

1.02- 3.65

HCV-Ab

 Negative

266 (93.01%)

reference

 Positive

20 (6.99%)

1.17

0.67–2.07

0.5795

Adjacent to large blood vessels

 Without

196 (68.53%)

reference

 With

90 (31.47%)

1.17

0.84–1.61

0.3517

Adjacent to the diaphragm

 Without

262 (91.61%)

reference

 With

24 (8.39%)

2.14

1.34–3.42

0.0014

1.24

0.74–2.09

MVI classification

 M1

132 (46.15%)

reference

reference

reference

 M2

66 (23.08%)

2.7

1.83–3.99

 < 0.0001

2.14

1.41–3.25

2.3

1.17- 4.52

 MX

88 (30.77%)

1.7

1.17–2.47

0.0054

1.29

0.86–1.93

1.65

0.88- 3.12

Largest tumor diameter (cm)

 ≤ 5

170 (59.44%)

reference

reference

 > 5

116 (40.56%)

1.99

1.46–2.71

 < 0.0001

1.56

1.10–2.22

1.78

1.01- 3.14

Number of tumors

 1

250 (87.41%)

reference

reference

reference

 ≥ 2

36 (12.59%)

1.77

1.17–2.66

0.0064

1.66

1.08–2.55

2.06

0.93- 4.56

Satellite nodule

 Without

237 (82.87%)

reference

reference

reference

 With

49 (17.13%)

1.79

1.23–2.59

0.0022

1.44

0.97–2.14

1.95

0.97- 3.91

Serosal invasion

 Without

114 (39.86%)

reference

reference

reference

 With

172 (60.14%)

1.97

1.41–2.76

 < 0.0001

1.59

1.11–2.28

2.06

1.17- 3.64

Preoperative/intraoperative ablation

 Without

279 (97.55%)

reference

 With

7 (2.45%)

1.07

0.34–3.35

0.9105

Preoperative radiotherapy

 Without

280 (97.90%)

reference

 With

6 (2.10%)

1.08

0.34–3.38

0.9000

Preoperative interventional therapy

 Without

270 (94.41%)

reference

 With

16 (5.59%)

1.56

0.85–2.88

0.1536

Postoperative radiotherapy

 Without

239 (83.57%)

reference

 With

47 (16.43%)

0.89

0.59–1.35

0.5919

Postoperative interventional therapy

 Without

172 (60.14%)

reference

 With

114 (39.86%)

1.23

0.90–1.67

0.1919