Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

Table 3 Transduction efficiency and VCN

CAR products			Transduction efficiency (%)	VCN
CART Bags Leftover	#1	tisa-cel	11.2	0.86
	#2		13.9	0.69
	#3		14.7	1.06
	#4		46	1.09
	#5		17.7	0.62
	#6		10.1	1.69
	#7		16.6	0.69
	#8		11.4	2.0
	#9	axi-cel	58	2.33
	#10		78	1.45
	#11		78	0.95
	#12		67	1.21
Local production (experimental)	#13	IL-1RAP	11.1	2.5
	#14		55.8	1.8
	#15		24.5	1.9
	#16		18	1.8
Local production (GMP-like)	#17	IL-1RAP	55.3	1.2
	#18		15.9	1.7
	#19		23.9	2.8
	#20		23.4	3.0

ISSN: 1479-5876