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Table 2 Incidence rates, hazard ratio, and confidence intervals of TB infection in different stratifications

From: Increased risk of pulmonary and extrapulmonary tuberculosis infection in patients with polycystic kidney disease: a nationwide population-based study with propensity score-matching analysis

Variables

Non-PKD Cohort

PKD Cohort

PKD VS. Non-PKD

n = 6770

n = 6770

Crude HR

Adjusted HR

Event

Person years

IR

Event

Person years

IR

(95% CI)

(95% CI)

Overall

114

41,183

27.68

175

35,325

49.54

1.74(1.37–2.20)***

1.91(1.51–2.43)***

 PTB

90

41,243

21.82

121

35,514

34.07

1.52(1.16–2.00)**

1.69(1.29–2.22)**

 EPTB

22

41,386

5.32

44

35,565

12.37

2.28(1.37–3.80)**

2.44(1.46–4.08)***

Gender

 Female

25

18,070

13.84

46

16,280

28.25

2.00(1.23–3.26)**

2.22(1.36–3.62)**

 Male

89

23,114

38.51

129

19,045

67.73

1.70(1.30–2.23)***

1.84(1.4–2.41)***

Age at baseline

 20–49

5

14,842

3.37

14

14,217

9.85

2.88(1.04–7.99)*

3.29(1.14–9.47)*

 50–64

21

12,306

17.06

48

10,711

44.81

2.61(1.56–4.36)***

2.68(1.6–4.49)***

  > 65

88

14,035

62.70

113

10,397

108.68

1.66(1.25–2.19)***

1.66(1.25–2.19)***

Baseline comorbidity

 No

26

22,890

11.36

56

20,366

27.50

2.37(1.49–3.78)**

2.69(1.69–4.30)***

 Yes

88

18,294

48.10

119

14,960

79.55

1.60(1.22–2.11)***

1.71(1.30–2.26)***

 Hypertension

57

11,064

51.52

88

9052

97.22

1.84(1.32–2.56)***

1.89(1.35–2.64)***

 Hyperlipidemia

5

1918

26.07

14

1500

93.35

3.56(1.28–9.90)*

4.18(1.46–11.94)**

 Alcohol related disease

4

422

94.81

2

303

66.01

0.66(0.12–3.60)

1.52(0.18–13.01)

 Chronic kidney disease

45

6931

64.93

53

5666

93.54

1.40(0.94–2.08)

1.44(0.97–2.15)

 ESRD

14

3507

39.92

16

3030

52.80

1.28(0.62–2.62)

1.27(0.61–2.63)

 Chronic liver disease

20

2158

92.67

18

1654

108.85

1.13(0.60–2.14)

1.25(0.65–2.40)

 COPD

24

1583

151.66

22

1253

175.54

1.09(0.61–1.94)

1.19(0.66–2.15)

 Diabetes

15

2916

51.44

25

2437

102.57

1.95(1.03–3.69)*

1.92(1.01–3.66)*

 Bacterial infection

50

7999

62.51

47

6885

68.27

1.06(0.71–1.58)

1.12(0.75–1.68)

 Viral infection

15

2484

60.39

22

1880

117.03

1.86(0.96–3.59)

1.82(0.93–3.57)

 Pneumoconiosis

7

222

314.69

4

213

187.37

0.64(0.19–2.19)

0.69(0.17–2.72)

  1. IR incidence rates, per 10,000 person-years, HR hazard ratio, CI confidence interval
  2. Adjusted HR: adjusted for age, all comorbidities in Cox proportional hazards regression
  3. *p < 0.05, **p < 0.01, ***p < 0.001
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Journal of Translational Medicine

ISSN: 1479-5876

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