Fig. 8From: ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axisThe molecular mechanism plot for the role of ELK4 in GC by regulating KDM5A/PJA2/KSR1 axis. ELK4 may inhibit PJA2 expression through transcriptional activation of KDM5A, which reduces the ubiquitination of KSR1, promoting M2 polarization of macrophages and thus facilitating the development of GCBack to article page