Fig. 8

The molecular mechanism plot for the role of ELK4 in GC by regulating KDM5A/PJA2/KSR1 axis. ELK4 may inhibit PJA2 expression through transcriptional activation of KDM5A, which reduces the ubiquitination of KSR1, promoting M2 polarization of macrophages and thus facilitating the development of GC