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Table 2 Most significant KEGG pathways with altered expression in terms of disease

From: Characterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression

Name of pathway

Count

p-value

Fold enrichment

FDR

CCGs

 Oxidative phosphorylation

22

3.18E−19

12.11

2.62E−14

 *Parkinson’s disease

21

2.63E−17

10.82

1.81E−12

 Alzheimer’s disease

22

4.60E−17

9.58

3.75E−12

 *Non-alcoholic fatty liver disease (NAFLD)

21

1.12E−14

8.00

6.41E−10

 Huntington’s disease

19

2.72E−14

9.21

1.05E−09

 Metabolic pathways

41

7.24E−12

2.52

3.04E−06

ICGs

 Vitamin digestion and absorption

8

1.22E−7

18.53

1.52E−04

 Fat digestion and absorption

41

3.57E−4

1.71

0.4450

 Protein digestion and absorption

6

8.80E−4

7.84

1.0931

 Metabolic pathways

8

1.63E−3

4.63

1.9248

 Chemical carcinogenesis

7

4.53E−3

4.46

5.4888

  1. * Indicates the associations with CD were previously reported. Count: number of genes; p-value: modified Fisher Exact p-value, EASE Score, the smaller, the more enriched; Fold Enrichment: − log (p-value); CCGs: colonic CD genes; ICGs: terminal-ileal CD genes