The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study

Table 3 Fold over basal (FOB) in chronic ischemic and non-ischemic muscle

Parameter	FOB in chronic ischemic muscle (gastrocnemius muscle)	FOB in non-ischemic muscle (lateral vastus muscle)	p-value
CSA (nmol/min/mg protein)	1.37 (1.10–1.64)	0.93 (0.69–1.16)	0.020
MOct_L per CSA	0.83 (0.44–1.22)	1.39 (0.74–2.05)	0.037
MOct_P per CSA	0.87 (0.28–1.45)	1.47 (0.56–2.37)	0.020
P per CSA	0.64 (0.46–0.82)	1.16 (0.77–1.54)	0.011
E per CSA	0.61 (0.47–0.76)	1.02 (0.64–1.40)	0.010

Fold over basal (FOB) in chronic ischemic and non-ischemic muscle; Data are expressed as median with IQR in brackets; A p-value < 0.05 is considered to be significant; CSA Citrate synthase activity, MOct_L maximal respiration after titration of malate and octanoyl; MOct_P maximal respiration after addition of ADP, P maximal respiration after addition of pyruvate and succinate; E maximal respiration after addition of FCCP

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