Fig. 7From: Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancerThe mechanism of MEG3 in EC. MEG3 was found to downregulate MDM2 to repress p53 ubiquitination and degradation, activating p53 to elevate miR-149-3p expression, which inhibited regulatory T cell differentiation and immune escape in EC mice by targeting FOXP3Back to article page