Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects

Table 1 Basal characteristics of CCS patients and controls

	CCS patients (n = 30)	Controls (n = 24)	p
Age, years	67 (62–73)	73 (67–75)	0.053
Males	23 (77)	17 (71)	0.429
Body mass index, kg/m²	27 (24–30)	25 (24–28)	0.192
Smoking
Current	1 (3.3)	0 (0)	0.556
Former	15 (50)	3 (13)	0.004
History of coronary event, ACS/SA	23 (77)/7 (23)	-
History of coronary revascularization, PCI/CABG^a	19 (63)/15 (50)	-
Severity of coronary artery disease, 1VD/2VD/3VD^b	7 (23)/9 (30)/14 (47)	-
Use of anti-hypertensive drugs	14 (47)	8 (33)	0.239
Use of statin	29 (97)	7 (29)	< 0.0001
LDL cholesterol, mmol/L	1.6 (1.4–1.9)	3 (2.2–3.5)	< 0.0001
oxLDL cholesterol, U/L	43 (38–53)	68 (55–75)	< 0.0001
oxLDL/LDL ratio	29 (24–35)	22 (20–27)	0.006
HDL cholesterol, mmol/L	1.4 (1.0–1.7)	1,4 (1.0–1.7)	0.662
Triglycerides, mmol/L	1.0 (0.7–1.5)	1.3 (0.8–1.6)	0.398
Creatinine, µmol/L	88 (78–97)	79 (73–92)	0.134
Fasting glucose, mmol/L	5.8 (5.3–6.6)	5.7 (5.2–6.3)	0.403
TAC in PBMCs, UAE/100 ug	0.97 (0.28–1.48)	1.53 (1.20–2.09)	0.001

Values are given as n (%) or median (interquartile range). CCS: chronic coronary syndrome; ACS: acute coronary syndrome; SA: stable angina; PCI: percutaneous coronary intervention; CABG; coronary artery bypass grafting; VD: vessel disease; LDL: low density lipoprotein; oxLDL: oxidized LDL; HDL: high density lipoprotein; TAC: total antioxidant capacity; PBMC: peripheral blood mononuclear cell; UAE: uric acid equivalents
^a Four patients had a previous history of PCI followed by CABG
^b Severity of coronary artery disease is indicated as ≥ 50% luminal narrowing in one, two or three major epicardial coronary arteries (i.e., the right coronary artery, left anterior descending artery, and left circumflex artery). Bolded P-values represent statistical significance

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