A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Table 2 Results of the gene-based likelihood ratio tests (p-values for each test are shown)

Disease/gene	HLA-A	HLA-B	HLA-C	HLA-DPB1	HLA-DQA1	HLA-DQB1	HLA-DRB1
Any infection	0.1759	0.6097	0.7975	0.6141	0.1708	0.5422	0.4631
Bacterial infection	0.3187	0.1235	0.05251	0.7455	0.7642	0.9248	0.8715
CNS infection	NA	NA	0.5737	0.01279^a	0.6255	0.477	NA
Gastrointestinal infection	0.5783	0.5979	0.9051	0.03784	0.09455	0.2796	0.4751
Genital infection	1	1	0.3614	0.1255	0.4617	0.2426	NA
Hepatitis infection	NA	NA	NA	NA	0.07716	0.6711	NA
Other infections	0.643	0.6957	0.9214	0.7476	0.01073^a	0.08866	0.4972
Otitis infection	0.02872	0.8145	0.6157	0.8382	0.8545	0.8985	0.5372
Pregnancy-related infection	0.6392	NA	0.7479	0.4424	0.8963	0.8691	NA
Respiratory infection	0.437	0.7647	0.2972	0.4032	0.1343	0.09267	0.1911
Sepsis	NA	NA	0.4429	0.7941	0.3766	0.003534^a	NA
Skin infection	0.5236	0.02606	0.2706	0.7474	0.5656	0.6319	0.816
Urological infection	0.6288	0.7088	0.02561	0.3027	0.9862	0.6622	0.6907
Viral infection	0.2659	0.2998	0.3384	0.3027	0.03678	0.01402^a	0.0467

NA denotes cases in which the regression/likelihood ratio test failed due to small sample sizes, multicollinearity of the alleles, and/or rare alleles
^aThese associations obtained the lowest q-value (27%)

ISSN: 1479-5876