Table 4 The work-flow of the literature review

1.Gut-brain-microbiota axis (GBMAx)

[1,2,3,4, 9,10,11,12,13,14,15]

2.microRNA( miRNA)

2.1.miRNA biogenesis

[16,17,18,19]

2.2.miRNA function

[20,21,22,23,24,25,26,27,28]

3.Gut microbiota-host miRNA interaction

3.1.gut microbiota-gut miRNA interaction

[7, 29,30,31,32,33,34,35,36,37,38,39,40,41,42,43]

3.2.gut microbiota-brain miRNA interaction

[44,45,46,47,48]

4. Extracellular vesicles (EVs)

4.1.EV biogenesis

[49,50,51,52,53,54,55, 82,83,84,85,86,87,88,89,90,91,92,93,94,95]

4.2.EV function

[60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81, 166,167,168,169,170,177, 172,173,174,175,176,171, 187,188,189,190,191]

4.3.Environmental and genetic influence

[178,179,180,181,182,183,184,185,186]

4.4.EV entrapment of fecal miRNA

[7, 96, 97]

4.5.Brain- derived EVs

[98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125]

4.6. Microbiota derived EVs

[126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165]